Gene
kmt2ba
- ID
- ZDB-GENE-060503-376
- Name
- lysine (K)-specific methyltransferase 2Ba
- Symbol
- kmt2ba Nomenclature History
- Previous Names
-
- mll4a
- si:rp71-15k1.2
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have histone methyltransferase activity (H3-K4 specific). Predicted to be involved in histone H3-K4 methylation and positive regulation of transcription, DNA-templated. Predicted to localize to histone methyltransferase complex. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; dystonia; and hepatocellular carcinoma. Orthologous to human KMT2B (lysine methyltransferase 2B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sun et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
dystonia 28, childhood-onset | Alliance | Dystonia 28, childhood-onset | 617284 |
Intellectual developmental disorder, autosomal dominant 68 | 619934 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR003888 | FY-rich, N-terminal |
Conserved_site | IPR003889 | FY-rich, C-terminal |
Domain | IPR001214 | SET domain |
Domain | IPR001965 | Zinc finger, PHD-type |
Domain | IPR002857 | Zinc finger, CXXC-type |
Domain | IPR003616 | Post-SET domain |
Domain | IPR019787 | Zinc finger, PHD-finger |
Domain | IPR034732 | Extended PHD (ePHD) domain |
Domain | IPR047219 | Histone-lysine N-methyltransferase 2A/2B, SET domain |
Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Homologous_superfamily | IPR036427 | Bromodomain-like superfamily |
Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
Protein | Length | Bromodomain-like superfamily | Extended PHD (ePHD) domain | FY-rich, C-terminal | FY-rich, N-terminal | Histone-lysine N-methyltransferase 2A/2B, SET domain | Post-SET domain | SET domain | SET domain superfamily | Zinc finger, CXXC-type | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, RING/FYVE/PHD-type |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2B683
|
2862 | |||||||||||||
UniProtKB:A0A8N7TDQ0
|
2863 | |||||||||||||
UniProtKB:A0A8M2B633
|
2862 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
antisense |
ottdart00000059906
(1)
|
Havana | 684 nt | |
mRNA |
kmt2ba-201
(1)
|
Havana | 9950 nt | |
mRNA |
kmt2ba-202
(1)
|
Ensembl | 11578 nt |
Interactions and Pathways
No data available
Plasmids
No data available