Gene

vps8

ID

ZDB-GENE-060503-348

Name

VPS8 subunit of CORVET complex

Symbol

vps8 Nomenclature History

Previous Names

im:7166005
si:dkey-24b15.1 (1)
zgc:158695 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable metal ion binding activity. Predicted to be involved in endosomal vesicle fusion and protein targeting to vacuole. Predicted to act upstream of or within intracellular protein transport and vesicle-mediated transport. Predicted to be part of CORVET complex and HOPS complex. Predicted to be active in early endosome and late endosome. Orthologous to human VPS8 (VPS8 subunit of CORVET complex).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7166005 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vps8 Human Ortholog

No data available

Associated With vps8 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR025941	Vacuolar protein sorting-associated protein 8, central domain
Family	IPR045111	Vacuolar protein sorting-associated protein Vps41/Vps8
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	Vacuolar protein sorting-associated protein 8, central domain	Vacuolar protein sorting-associated protein Vps41/Vps8	WD40 repeat	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily	Zinc finger, RING/FYVE/PHD-type	Zinc finger, RING-type
UniProtKB:A0A8M3AQ47 InterPro	1414
UniProtKB:F1QQ05 InterPro	1412

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	vps8-201 (1) Ensembl	Ensembl	1,528 nt	Select Tool ZFIN BLAST
mRNA	vps8-202 (1) Ensembl	Ensembl	687 nt	Select Tool ZFIN BLAST
mRNA	vps8-203 (1) Ensembl	Ensembl	4,399 nt	Select Tool ZFIN BLAST
mRNA	vps8-204 (1) Ensembl	Ensembl	830 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations