Gene

rad21b

ID

ZDB-GENE-060503-223

Name

RAD21 cohesin complex component b

Symbol

rad21b Nomenclature History

Previous Names

si:ch211-246f9.1

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to enable chromatin binding activity. Predicted to be involved in replication-born double-strand break repair via sister chromatid exchange and sister chromatid cohesion. Predicted to act upstream of or within chromosome segregation. Predicted to be located in nucleus. Predicted to be part of cohesin complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human RAD21 (RAD21 cohesin complex component).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rad21b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Cornelia de Lange syndrome 4	Alliance	Cornelia de Lange syndrome 4	614701
		?Mungan syndrome	611376

Associated With rad21b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006909	Rad21/Rec8-like protein, C-terminal, eukaryotic
Domain	IPR006910	Rad21/Rec8-like protein, N-terminal
Domain	IPR049589	NXP-1, middle HEAT-repeat binding domain
Family	IPR039781	Rad21/Rec8-like protein
Homologous_superfamily	IPR023093	ScpA-like, C-terminal
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily