Gene

nfixb

ID

ZDB-GENE-060421-5000

Name

nuclear factor I/Xb

Symbol

nfixb Nomenclature History

Previous Names

zgc:136878

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within DNA replication and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in dorsal telencephalon; midbrain; muscle; and telencephalon. Human ortholog(s) of this gene implicated in Marshall-Smith syndrome and Sotos syndrome 2. Orthologous to human NFIX (nuclear factor I X).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nfixb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Marshall-Smith syndrome	Alliance	Marshall-Smith syndrome	602535
Sotos syndrome 2	Alliance	Malan syndrome	614753

Associated With nfixb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019739	CTF transcription factor/nuclear factor 1, conserved site
Domain	IPR003619	MAD homology 1, Dwarfin-type
Domain	IPR019548	CTF transcription factor/nuclear factor 1, N-terminal
Domain	IPR020604	CTF transcription factor/nuclear factor 1, DNA-binding domain
Family	IPR000647	CTF transcription factor/nuclear factor 1

Domain Details Per Protein

Protein	Length	CTF transcription factor/nuclear factor 1	CTF transcription factor/nuclear factor 1, conserved site	CTF transcription factor/nuclear factor 1, DNA-binding domain	CTF transcription factor/nuclear factor 1, N-terminal	MAD homology 1, Dwarfin-type
UniProtKB:A0A8M3B860 InterPro	562
UniProtKB:Q1RLS5 InterPro	440
UniProtKB:A0A8M2BAY5 InterPro	528
UniProtKB:A0A8M3AXV2 InterPro	530
UniProtKB:A0A8M3AQD9 InterPro	513
UniProtKB:A0A8M3AQR1 InterPro	556
UniProtKB:A0A8M2BBB5 InterPro	536
UniProtKB:A0A8M3AQR5 InterPro	561
UniProtKB:A0A8M3B0T9 InterPro	500
UniProtKB:A0A8M3B863 InterPro	512
UniProtKB:A0A8M3AXU6 InterPro	574
UniProtKB:A0A8M3AQD4 InterPro	573
UniProtKB:A0A8M3B0T6 InterPro	531