Gene
ddr1
- ID
- ZDB-GENE-060323-2
- Name
- discoidin domain receptor tyrosine kinase 1
- Symbol
- ddr1 Nomenclature History
- Previous Names
-
- im:7158194
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable collagen binding activity and protein tyrosine kinase collagen receptor activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway; positive regulation of neuron projection development; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in breast carcinoma; idiopathic pulmonary fibrosis; lung non-small cell carcinoma; osteosarcoma; and skin melanoma. Orthologous to human DDR1 (discoidin domain receptor tyrosine kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Conserved_site | IPR002011 | Tyrosine-protein kinase, receptor class II, conserved site |
| Domain | IPR000421 | Coagulation factor 5/8, C-terminal domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR048525 | Discoidin domain-containing receptor 1/2, DS-like domain |
| Family | IPR050122 | Receptor Tyrosine Kinase |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Coagulation factor 5/8, C-terminal domain | Discoidin domain-containing receptor 1/2, DS-like domain | Galactose-binding-like domain superfamily | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class II, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8RJX9
|
958 | ||||||||||
|
UniProtKB:A0A8M3AI21
|
936 | ||||||||||
|
UniProtKB:E7F3X9
|
974 |
Interactions and Pathways
No data available
Plasmids
No data available