Gene
arhgef7a
- ID
- ZDB-GENE-060322-11
- Name
- Rho guanine nucleotide exchange factor (GEF) 7a
- Symbol
- arhgef7a Nomenclature History
- Previous Names
-
- fc28d09
- wu:fc28d09
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in lamellipodium assembly. Predicted to act upstream of or within intracellular signal transduction. Predicted to be active in cytoplasm and lamellipodium. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7144067 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001331 | Guanine-nucleotide dissociation stimulator, CDC24, conserved site |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001715 | Calponin homology domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR032409 | Rho guanine nucleotide exchange factor 6/7, coiled-coil domain |
| Domain | IPR035788 | Rho guanine nucleotide exchange factor 6, SH3 domain |
| Domain | IPR046376 | RhoGEF 6/7, PH domain |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036872 | CH domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Calponin homology domain | CH domain superfamily | Dbl homology (DH) domain superfamily | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | PH-like domain superfamily | Pleckstrin homology domain | RhoGEF 6/7, PH domain | Rho guanine nucleotide exchange factor 6/7, coiled-coil domain | Rho guanine nucleotide exchange factor 6, SH3 domain | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B0S771 | InterPro | 858 | |||||||||||
| UniProtKB:A0A8M9QJM4 | InterPro | 702 | |||||||||||
| UniProtKB:A0A2R8Q515 | InterPro | 859 | |||||||||||
| UniProtKB:A0A8M6Z2J5 | InterPro | 782 | |||||||||||
| UniProtKB:A0A8M2BF23 | InterPro | 807 | |||||||||||
| UniProtKB:A0A8M2BF17 | InterPro | 777 | |||||||||||
| UniProtKB:A0A8M9Q4K4 | InterPro | 864 | |||||||||||
| UniProtKB:A0A8M2BEZ3 | InterPro | 802 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgef7a-202
(1)
|
Ensembl | 3,312 nt | ||
| mRNA |
arhgef7a-204
(1)
|
Ensembl | 6,971 nt | ||
| ncRNA |
arhgef7a-002
(1)
|
Ensembl | 2,491 nt | ||
| ncRNA |
arhgef7a-003
(1)
|
Ensembl | 556 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-278C10 | ||
| Contained in | BAC | DKEY-19J7 | ZFIN Curated Data | |
| Encodes | EST | fc28d09 | ||
| Encodes | EST | IMAGE:7144067 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001123235 (1) | 3312 nt | ||
| Genomic | GenBank:BX649266 (2) | 235135 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q4K4 (1) | 864 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Li, F., Wang, H., Liu, J., Lin, J., Zeng, A., Ai, W., Wang, X., Dahlgren, R.A., Wang, H. (2016) Immunotoxicity of β-Diketone Antibiotic Mixtures to Zebrafish (Danio rerio) by Transcriptome Analysis. PLoS One. 11:e0152530
- Tsai, H.Y., Hamilton, A., Tinch, A.E., Guy, D.R., Gharbi, K., Stear, M.J., Matika, O., Bishop, S.C., Houston, R.D. (2015) Genome wide association and genomic prediction for growth traits in juvenile farmed Atlantic salmon using a high density SNP array. BMC Genomics. 16:969
- Tay, H.G., Ng, Y.W., and Manser, E. (2010) A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly. PLoS One. 5(4):e10125
- Okuda, Y., Yoda, H., Uchikawa, M., Furutani-Seiki, M., Takeda, H., Kondoh, H., Kamachi, Y. (2006) Comparative genomic and expression analysis of group B1 sox genes in zebrafish indicates their diversification during vertebrate evolution. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(3):811-825
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