Gene
slc6a4b
- ID
- ZDB-GENE-060314-2
- Name
- solute carrier family 6 member 4b
- Symbol
- slc6a4b Nomenclature History
- Previous Names
-
- sertb (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable serotonin binding activity and serotonin:sodium:chloride symporter activity. Predicted to be involved in amino acid transport; serotonin uptake; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in male organism and nervous system. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; anxiety disorder (multiple); depressive disorder (multiple); heart disease (multiple); and substance abuse (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| anxiety disorder | Alliance | {Anxiety-related personality traits} | 607834 |
| {Obsessive-compulsive disorder} | 164230 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Sodium:neurotransmitter symporter | Sodium:neurotransmitter symporter superfamily |
|---|---|---|---|
|
UniProtKB:B3DJ31
|
591 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc6a4b-201
(1)
|
Ensembl | 1,852 nt |
Interactions and Pathways
No data available
Plasmids
No data available