Gene
irge4
- ID
- ZDB-GENE-051212-2
- Name
- immunity-related GTPase family, e4
- Symbol
- irge4 Nomenclature History
- Previous Names
-
- zgc:158767
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity and GTPase activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sieger et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Immunity-related GTPase | Immunity-related GTPases-like | IRG-type guanine nucleotide-binding (G) domain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P7N2
|
772 | ||||
|
UniProtKB:A2RV34
|
385 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-175G6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158767 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001083032 (1) | 1882 nt | ||
| Genomic | GenBank:CR391937 (2) | 224481 nt | ||
| Polypeptide | UniProtKB:A0A8M9P7N2 (1) | 772 aa |
No data available
- Ding, Y., Tong, J., Luo, G., Sun, R., Bei, C., Feng, Z., Meng, L., Wang, F., Zhou, J., Chen, Z., Li, D., Fan, Y., Song, S., Wang, D., Feng, C.G., Liu, H., Chen, Q., Yan, B., Gao, Q. (2024) Mycobacterial CpsA activates type I IFN signaling in macrophages via cGAS-mediated pathway. iScience. 27:109807109807
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Sieger, D., Stein, C., Neifer, D., van der Sar, A.M., and Leptin, M. (2009) The role of gamma interferon in innate immunity in the zebrafish embryo. Disease models & mechanisms. 2(11-12):571-581
- Bekpen, C., Hunn, J.P., Rohde, C., Parvanova, I., Guethlein, L., Dunn, D.M., Glowalla, E., Leptin, M., and Howard, J.C. (2005) The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage. Genome biology. 6(11):R92
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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