Gene
naga
- ID
- ZDB-GENE-051113-256
- Name
- N-acetylgalactosaminidase, alpha
- Symbol
- naga Nomenclature History
- Previous Names
-
- zgc:123333
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable alpha-galactosidase activity. Predicted to be involved in glycoside catabolic process and oligosaccharide metabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in lysosome. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Kanzaki disease; Schindler disease type 1; angiokeratoma; and neuroaxonal dystrophy. Orthologous to human NAGA (alpha-N-acetylgalactosaminidase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Kanzaki disease | Alliance | Kanzaki disease | 609242 |
| Schindler disease type 1 | Alliance | Schindler disease, type I | 609241 |
| Schindler disease type 1 | Alliance | Schindler disease, type III | 609241 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000111 | Glycoside hydrolase family 27/36, conserved site |
| Domain | IPR035373 | Alpha galactosidase A, C-terminal beta-sandwich domain |
| Family | IPR002241 | Glycoside hydrolase, family 27 |
| Homologous_superfamily | IPR013780 | Glycosyl hydrolase, all-beta |
| Homologous_superfamily | IPR013785 | Aldolase-type TIM barrel |
| Homologous_superfamily | IPR017853 | Glycoside hydrolase superfamily |
Domain Details Per Protein
| Protein | Length | Aldolase-type TIM barrel | Alpha galactosidase A, C-terminal beta-sandwich domain | Glycoside hydrolase, family 27 | Glycoside hydrolase family 27/36, conserved site | Glycoside hydrolase superfamily | Glycosyl hydrolase, all-beta |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IJL2
|
437 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available