Gene

dnm2a

ID

ZDB-GENE-050913-84

Name

dynamin 2a

Symbol

dnm2a Nomenclature History

Previous Names

dnm2
zgc:114072

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have GTPase activity and microtubule binding activity. Involved in several processes, including chordate embryonic development; convergent extension; and somite development. Predicted to localize to several cellular components, including dendritic spine head; postsynaptic density; and postsynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Is expressed in several structures, including central nervous system; liver; otic vesicle; paraxial mesoderm; and pericardial region. Orthologous to human DNM2 (dynamin 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dnm2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
centronuclear myopathy 1	Alliance	Centronuclear myopathy 1	160150
Charcot-Marie-Tooth disease dominant intermediate B	Alliance	Charcot-Marie-Tooth disease, axonal type 2M	606482
Charcot-Marie-Tooth disease dominant intermediate B	Alliance	Charcot-Marie-Tooth disease, dominant intermediate B	606482
		Lethal congenital contracture syndrome 5	615368

Associated With dnm2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019762	Dynamin, GTPase region, conserved site
Domain	IPR000375	Dynamin stalk domain
Domain	IPR001401	Dynamin, GTPase domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR003130	Dynamin GTPase effector
Domain	IPR020850	GTPase effector domain
Domain	IPR030381	Dynamin-type guanine nucleotide-binding (G) domain
Domain	IPR045063	Dynamin, N-terminal
Family	IPR022812	Dynamin
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	Dynamin	Dynamin, GTPase domain	Dynamin GTPase effector	Dynamin, GTPase region, conserved site	Dynamin, N-terminal	Dynamin stalk domain	Dynamin-type guanine nucleotide-binding (G) domain	GTPase effector domain	PH-like domain superfamily	Pleckstrin homology domain	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A0R4IIR1 InterPro	860
UniProtKB:T1SXK0 InterPro	856
UniProtKB:A0A8M9PW32 InterPro	860
UniProtKB:A0A8M9P798 InterPro	867
UniProtKB:A0A8M9PHU4 InterPro	856
UniProtKB:Q4V8Z7 InterPro	755
UniProtKB:A0A8M9PNW1 InterPro	878
UniProtKB:A0A8M9PZL4 InterPro	874
UniProtKB:A0A8M9PHT6 InterPro	885

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dnm2a-201 (1) Ensembl	Ensembl	2,573 nt	Select Tool
mRNA	dnm2a-202 (1) Ensembl	Ensembl	2,583 nt	Select Tool ZFIN BLAST
mRNA	dnm2a-203 (1) Ensembl	Ensembl	3,278 nt	Select Tool ZFIN BLAST
ncRNA	dnm2a-002 (1) Ensembl	Ensembl	770 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations