Gene
grapb
- ID
- ZDB-GENE-050913-4
- Name
- GRB2 related adaptor protein b
- Symbol
- grapb Nomenclature History
- Previous Names
-
- si:dkeyp-9d4.1
- zgc:109892
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable epidermal growth factor receptor binding activity and phosphotyrosine residue binding activity. Predicted to be involved in regulation of MAPK cascade and signal transduction. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm; nucleoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 114. Orthologous to human GRAP (GRB2 related adaptor protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Banerjee et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 114 | Alliance | Deafness, autosomal recessive 114 | 618456 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Grb2-like | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:F1QSQ4
|
214 |
Interactions and Pathways
No data available
Plasmids
No data available