Gene
camk2g1
- ID
- ZDB-GENE-050913-146
- Name
- calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
- Symbol
- camk2g1 Nomenclature History
- Previous Names
-
- camk2ga
- zgc:109908
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables calcium/calmodulin-dependent protein kinase activity. Involved in pronephros structural organization. Acts upstream of or within several processes, including heart jogging; inner ear receptor cell differentiation; and protein autophosphorylation. Predicted to be active in cytoplasm; neuron projection; and postsynaptic density. Is expressed in several structures, including gut; nervous system; neural tube; notochord; and pronephric duct. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human CAMK2G (calcium/calmodulin dependent protein kinase II gamma).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109908 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns508 | Allele with one delins | Unknown | Unknown | CRISPR | |
| la027346Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nk4cEt | Transgenic insertion | Unknown | Unknown | DNA | |
| sa31890 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa44771 | Allele with one point mutation | Unknown | Unknown | ENU | |
| va5 | Allele with one delins | Unknown | Premature Stop | TALEN |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 59 | Alliance | Intellectual developmental disorder, autosomal dominant 59 | 618522 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR013543 | Calcium/calmodulin-dependent protein kinase II, association-domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
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Domain Details Per Protein
| Protein | Length | Calcium/calmodulin-dependent protein kinase II, association-domain | NTF2-like domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B2D8
|
624 | ||||||
|
UniProtKB:A0A8M9QEF1
|
595 | ||||||
|
UniProtKB:Q4V9P8
|
560 | ||||||
|
UniProtKB:A0A8M2B2F0
|
574 | ||||||
|
UniProtKB:A0A8M2B384
|
522 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
camk2g1-201
(1)
|
Ensembl | 4,445 nt | ||
| mRNA |
camk2g1-202
(1)
|
Ensembl | 636 nt | ||
| mRNA |
camk2g1-204
(1)
|
Ensembl | 1,219 nt | ||
| ncRNA |
camk2g1-002
(1)
|
Ensembl | 1,097 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-318O9 | ZFIN Curated Data | |
| Contained in | BAC | CH211-145J10 | ZFIN Curated Data | |
| Contained in | BAC | CH211-237E12 | ZFIN Curated Data | |
| Contained in | Fosmid | ZFOS-1145B8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109908 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030125 (1) | 2382 nt | ||
| Genomic | GenBank:CT573275 (1) | 152217 nt | ||
| Polypeptide | UniProtKB:A0A8M2B2E6 (1) | 627 aa |
- Juan, T., Ribeiro da Silva, A., Cardoso, B., Lim, S., Charteau, V., Stainier, D.Y.R. (2023) Multiple pkd and piezo gene family members are required for atrioventricular valve formation. Nature communications. 14:214214
- McLeod, J.J., Rothschild, S.C., Francescatto, L., Kim, H., Tombes, R.M. (2023) Specific CaMKIIs mediate convergent extension cell movements in early zebrafish development. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(4):390-403
- Chen, X.K., Kwan, J.S., Wong, G.T., Yi, Z.N., Ma, A.C., Chang, R.C. (2022) Leukocyte invasion of the brain after peripheral trauma in zebrafish (Danio rerio). Experimental & molecular medicine. 54(7):973-987
- Müller, M., Eghbalian, R., Boeckel, J.N., Frese, K.S., Haas, J., Kayvanpour, E., Sedaghat-Hamedani, F., Lackner, M.K., Tugrul, O.F., Ruppert, T., Tappu, R., Martins Bordalo, D., Kneuer, J.M., Piekarek, A., Herch, S., Schudy, S., Keller, A., Grammes, N., Bischof, C., Klinke, A., Cardoso-Moreira, M., Kaessmann, H., Katus, H.A., Frey, N., Steinmetz, L.M., Meder, B. (2022) NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart. Nature communications. 13:6209
- Holler, K., Neuschulz, A., Drewe-Boß, P., Mintcheva, J., Spanjaard, B., Arsiè, R., Ohler, U., Landthaler, M., Junker, J.P. (2021) Spatio-temporal mRNA tracking in the early zebrafish embryo. Nature communications. 12:3358
- Sitaraman, S., Yadav, G., Agarwal, V., Jabeen, S., Verma, S., Jadhav, M., Thirumalai, V. (2021) Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons. eLIFE. 10:
- Rothschild, S.C., Ingram, S.R., Lu, F.I., Thisse, B., Thisse, C., Parkerson, J.A., Tombes, R.M. (2020) Genetic compensation of γ CaMKII, an evolutionarily conserved gene. Gene. 742:144567
- Rothschild, S.C., Lee, H.J., Ingram, S.R., Mohammadi, D.K., Walsh, G.S., Tombes, R.M. (2018) Calcium Signals Act Through Histone Deacetylase to Mediate Pronephric Kidney Morphogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 247(6):807-817
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Burger, A., Lindsay, H., Felker, A., Hess, C., Anders, C., Chiavacci, E., Zaugg, J., Weber, L.M., Catena, R., Jinek, M., Robinson, M.D., Mosimann, C. (2016) Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes. Development (Cambridge, England). 143(11):2025-37
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