Gene
cast
- ID
- ZDB-GENE-050810-2
- Name
- calpastatin
- Symbol
- cast Nomenclature History
- Previous Names
-
- sb:cb966 (1)
- zgc:194249
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable calcium-dependent cysteine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; embryonic structure; epidermis; pectoral fin; and periderm. Human ortholog(s) of this gene implicated in PLACK syndrome; Parkinson's disease; autoimmune disease (multiple); congenital myasthenic syndrome 1A; and vasculitis. Orthologous to human CAST (calpastatin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb966 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| PLACK syndrome | Alliance | Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads | 616295 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cast-201
(1)
|
Ensembl | 2,527 nt | ||
| mRNA |
cast-202
(1)
|
Ensembl | 710 nt | ||
| mRNA |
cast-203
(1)
|
Ensembl | 3,766 nt | ||
| mRNA |
cast-204
(1)
|
Ensembl | 1,062 nt | ||
| mRNA |
cast-205
(1)
|
Ensembl | 895 nt | ||
| mRNA |
cast-207
(1)
|
Ensembl | 729 nt | ||
| mRNA |
cast-208
(1)
|
Ensembl | 645 nt | ||
| mRNA |
cast-209
(1)
|
Ensembl | 977 nt | ||
| mRNA |
cast-211
(1)
|
Ensembl | 462 nt | ||
| mRNA |
cast-212
(1)
|
Ensembl | 762 nt | ||
| mRNA |
cast-213
(1)
|
Ensembl | 843 nt | ||
| mRNA |
cast-214
(1)
|
Ensembl | 398 nt | ||
| mRNA |
cast-215
(1)
|
Ensembl | 576 nt | ||
| mRNA |
cast-216
(1)
|
Ensembl | 747 nt | ||
| mRNA |
cast-217
(1)
|
Ensembl | 2,515 nt | ||
| mRNA |
cast-218
(1)
|
Ensembl | 2,443 nt | ||
| mRNA |
cast-219
(1)
|
Ensembl | 2,734 nt | ||
| ncRNA |
cast-014
(1)
|
Ensembl | 328 nt | ||
| ncRNA |
cast-015
(1)
|
Ensembl | 467 nt |
Interactions and Pathways
No data available
Plasmids
No data available