Gene
acsl1a
- ID
- ZDB-GENE-050809-115
- Name
- acyl-CoA synthetase long chain family member 1a
- Symbol
- acsl1a Nomenclature History
- Previous Names
-
- acsl1
- zgc:110081
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable arachidonate-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process; long-chain fatty-acyl-CoA biosynthetic process; and very long-chain fatty acid metabolic process. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Orthologous to human ACSL1 (acyl-CoA synthetase long chain family member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu853 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la011400Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la013579Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021010Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa11697 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa13904 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19462 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zko332a | Allele with one deletion | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AMP-binding, conserved site | AMP-dependent synthetase/ligase domain | ANL, N-terminal domain | Long-chain fatty acid CoA synthetase, eukaryotic |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BFN1 | InterPro | 697 | ||||
| UniProtKB:Q499A9 | InterPro | 697 | ||||
| UniProtKB:B8JK22 | InterPro | 697 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
acsl1a-201
(1)
|
Ensembl | 4,370 nt | ||
| mRNA |
acsl1a-202
(1)
|
Ensembl | 2,925 nt | ||
| mRNA |
acsl1a-204
(1)
|
Ensembl | 708 nt | ||
| ncRNA |
acsl1a-002
(1)
|
Ensembl | 559 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-197N1 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-228C11 | ZFIN Curated Data | |
| Encodes | EST | eu853 | Thisse et al., 2005 | |
| Encodes | EST | fc74a12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110081 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174617 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001031837 (1) | 3248 nt | ||
| Genomic | GenBank:BX537280 (1) | 163151 nt | ||
| Polypeptide | UniProtKB:A0A8M2BFN1 (1) | 697 aa |
- Gao, P., Jia, D., Li, P., Huang, Y., Hu, H., Sun, K., Lv, Y., Chen, X., Han, Y., Zhang, Z., Ren, X., Wang, Q., Liu, F., Tang, Z., Liu, M. (2022) Accumulation of Lipid Droplets in a Novel Bietti Crystalline Dystrophy Zebrafish Model With Impaired PPARα Pathway. Investigative ophthalmology & visual science. 63:32
- Gasanov, E.V., Jędrychowska, J., Kuźnicki, J., Korzh, V. (2021) Evolutionary context can clarify gene names: Teleosts as a case study. BioEssays : news and reviews in molecular, cellular and developmental biology. 43(6):e2000258
- Park, K.H., Gooz, M., Ye, Z.W., Zhang, J., Beeson, G.C., Rockey, D.C., Kim, S.H. (2021) Flavin Adenine Dinucleotide Depletion Caused by electron transfer flavoprotein subunit alpha Haploinsufficiency Leads to Hepatic Steatosis and Injury in Zebrafish. Hepatology communications. 5:976-991
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Han, S.L., Liu, Y., Limbu, S.M., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2020) The reduction of lipid-sourced energy production caused by ATGL inhibition cannot be compensated by activation of HSL, autophagy, and utilization of other nutrients in fish. Fish physiology and biochemistry. 47(1):173-188
- Nath, A.K., Ma, J., Chen, Z.Z., Li, Z., Vitery, M.D.C., Kelley, M.L., Peterson, R.T., Gerszten, R.E., Yeh, J.J. (2020) Genetic deletion of gpr27 alters acylcarnitine metabolism, insulin sensitivity, and glucose homeostasis in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34:1546-1557
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Pan, Y.X., Zhuo, M.Q., Li, D.D., Xu, Y.H., Wu, K., Luo, Z. (2018) SREBP-1 and LXRα pathways mediated Cu-induced hepatic lipid metabolism in zebrafish Danio rerio. Chemosphere. 215:370-379
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Navarro-Martín, L., Oliveira, E., Casado, M., Barata, C., Piña, B. (2017) Dysregulatory effects of retinoic acid isomers in late zebrafish embryos. Environmental science and pollution research international. 25(4):3849-3859
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