Gene

slc8a1a

ID

ZDB-GENE-050809-1

Name

solute carrier family 8 member 1a

Symbol

slc8a1a Nomenclature History

Previous Names

ncx1 (1)
ncx1a (1)
ncx1h (1)
tre
tremblor

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Exhibits calcium:sodium antiporter activity. Involved in several processes, including calcium ion transport; cellular calcium ion homeostasis; and sarcomere organization. Predicted to localize to membrane. Human ortholog(s) of this gene implicated in hypertension. Is expressed in heart primordium and pericardial region. Orthologous to human SLC8A1 (solute carrier family 8 member A1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 21 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc8a1a Human Ortholog

No data available

Associated With slc8a1a Via Experimental Models

Human Disease	Fish	Conditions	Citations
atrial fibrillation	slc8a1a^{tc318d/tc318d}; twu34Tg	standard conditions	Sander et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003644	Na-Ca exchanger/integrin-beta4
Domain	IPR004837	Sodium/calcium exchanger membrane region
Domain	IPR032452	Sodium/calcium exchanger domain, C-terminal extension
Family	IPR004836	Sodium/calcium exchanger protein
Homologous_superfamily	IPR038081	CalX-like domain superfamily
Homologous_superfamily	IPR044880	NCX, central ion-binding domain superfamily