necab2

ID

ZDB-GENE-050706-167

Name

N-terminal EF-hand calcium binding protein 2

Symbol

necab2 Nomenclature History

Previous Names

im:6912315
zgc:112232 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including glutamatergic synaptic transmission; psychomotor behavior; and regulation of GABAergic synaptic transmission. Predicted to be located in synapse. Predicted to be active in cytoplasm. Is expressed in nervous system. Used to study autism spectrum disorder. Orthologous to human NECAB2 (N-terminal EF-hand calcium binding protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6912315 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Chen et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With necab2 Human Ortholog

No data available

Associated With necab2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
autism spectrum disorder	necab2^s4301/s4301	standard conditions	Chen et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Domain	IPR002048	EF-hand domain
Domain	IPR007138	Antibiotic biosynthesis monooxygenase domain
Family	IPR039862	N-terminal EF-hand calcium binding protein 1/2/3
Homologous_superfamily	IPR011008	Dimeric alpha-beta barrel
Homologous_superfamily	IPR011992	EF-hand domain pair