Gene
tdg.1
- ID
- ZDB-GENE-050522-44
- Name
- thymine DNA glycosylase, tandem duplicate 1
- Symbol
- tdg.1 Nomenclature History
- Previous Names
-
- tdg
- wu:fb44b11
- zgc:110622
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable pyrimidine-specific mismatch base pair DNA N-glycosylase activity and uracil DNA N-glycosylase activity. Predicted to be involved in base-excision repair, AP site formation. Predicted to act upstream of or within DNA repair. Predicted to be active in nucleus. Is expressed in retina. Orthologous to human TDG (thymine DNA glycosylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110622 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Manesia et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-tdg.1 | N/A | Rai et al., 2010 |
| MO2-tdg.1 | N/A | Manesia et al., 2017 |
| MO3-tdg.1 | N/A | Manesia et al., 2017 |
1 - 3 of 3
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | G/T mismatch-specific thymine DNA glycosylasee TDG-like, eukaryotes | Uracil DNA glycosylase family 2 | Uracil-DNA glycosylase-like | Uracil-DNA glycosylase-like domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q503G3 | InterPro | 441 | ||||
| UniProtKB:A0A8M2BA24 | InterPro | 404 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-68A17 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-218L23 | ZFIN Curated Data | |
| Encodes | EST | fb44b11 | ||
| Encodes | cDNA | MGC:110622 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192973 | ZFIN Curated Data |
1 - 5 of 5
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020751 (1) | 2732 nt | ||
| Genomic | GenBank:BX897714 (1) | 184435 nt | ||
| Polypeptide | UniProtKB:Q503G3 (1) | 441 aa |
- Manesia, J.K., Franch, M., Tabas-Madrid, D., Nogales-Cadenas, R., Vanwelden, T., Van Den Bosch, E., Xu, Z., Pascual-Montano, A., Khurana, S., Verfaillie, C. (2017) Distinct molecular signature of murine fetal liver and adult hematopoietic stem cells identifies novel regulators of hematopoietic stem cell function. Stem cells and development. 26(8):573-584
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Dhliwayo, N., Sarras, M.P., Luczkowski, E., Mason, S., Intine, R.V. (2014) Parp inhibition prevents ten eleven translocase enzyme activation and hyperglycemia induced DNA demethylation. Diabetes. 63(9):3069-76
- Ge, L., Zhang, R.P., Wan, F., Guo, D.Y., Wang, P., Xiang, L.X., and Shao, J.Z. (2014) TET2 Plays an Essential Role in Erythropoiesis by Regulating Lineage-Specific Genes via DNA Oxidative Demethylation in a Zebrafish Model. Molecular and cellular biology. 34(6):989-1002
- Lambert, M.J., Olsen, K.G., Cooper, C.D. (2014) Gene duplication followed by exon structure divergence substitutes for alternative splicing in zebrafish. Gene. 546(2):271-6
- Hirose, K., Shimoda, N., and Kikuchi, Y. (2013) Transient reduction of 5-methylcytosine and 5-hydroxymethylcytosine is associated with active DNA demethylation during regeneration of zebrafish fin. Epigenetics. 8(9):899-906
- Powell, C., Grant, A.R., Cornblath, E., and Goldman, D. (2013) Analysis of DNA methylation reveals a partial reprogramming of the Muller glia genome during retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 110(49):19814-19819
- Powell, C., Elsaeidi, F., and Goldman, D. (2012) Injury-Dependent Muller Glia and Ganglion Cell Reprogramming during Tissue Regeneration Requires Apobec2a and Apobec2b. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(3):1096-1109
- Rai, K., Sarkar, S., Broadbent, T.J., Voas, M., Grossmann, K.F., Nadauld, L.D., Dehghanizadeh, S., Hagos, F.T., Li, Y., Toth, R.K., Chidester, S., Bahr, T.M., Johnson, W.E., Sklow, B., Burt, R., Cairns, B.R., and Jones, D.A. (2010) DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC. Cell. 142(6):930-942
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 10 of 10
Show