Gene
gdap1
- ID
- ZDB-GENE-050522-424
- Name
- ganglioside induced differentiation associated protein 1
- Symbol
- gdap1 Nomenclature History
- Previous Names
-
- si:rp71-1m12.2
- zgc:112286
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to be involved in mitochondrial fission; mitochondrial fusion; and protein targeting to mitochondrion. Predicted to localize to integral component of mitochondrial outer membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease axonal type 2C; Charcot-Marie-Tooth disease axonal type 2K; Charcot-Marie-Tooth disease recessive intermediate A; and Charcot-Marie-Tooth disease type 4A. Is expressed in central nervous system and cranial ganglion. Orthologous to human GDAP1 (ganglioside induced differentiation associated protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112286 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Gonzaga-Jauregui et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease axonal type 2K | Alliance | Charcot-Marie-Tooth disease, axonal, type 2K | 607831 |
| Charcot-Marie-Tooth disease recessive intermediate A | Alliance | Charcot-Marie-Tooth disease, recessive intermediate, A | 608340 |
| Charcot-Marie-Tooth disease type 4A | Alliance | Charcot-Marie-Tooth disease, type 4A | 214400 |
| Charcot-Marie-Tooth disease, axonal, with vocal cord paresis | 607706 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004045 | Glutathione S-transferase, N-terminal |
| Domain | IPR010987 | Glutathione S-transferase, C-terminal-like |
| Domain | IPR034336 | Ganglioside-induced differentiation-associated protein 1, C-terminal domain |
| Family | IPR040079 | Glutathione transferase family |
| Homologous_superfamily | IPR036249 | Thioredoxin-like superfamily |
| Homologous_superfamily | IPR036282 | Glutathione S-transferase, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Ganglioside-induced differentiation-associated protein 1, C-terminal domain | Glutathione S-transferase, C-terminal domain superfamily | Glutathione S-transferase, C-terminal-like | Glutathione S-transferase, N-terminal | Glutathione transferase family | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PXI3
|
216 | ||||||
|
UniProtKB:Q78AN2
|
362 | ||||||
|
UniProtKB:A0A8M2B9N6
|
280 |
Interactions and Pathways
No data available
Plasmids
No data available