Gene
mffb
- ID
- ZDB-GENE-050522-208
- Name
- mitochondrial fission factor b
- Symbol
- mffb Nomenclature History
- Previous Names
-
- im:5082098
- zgc:110130
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable protein homodimerization activity. Predicted to be involved in mitochondrion organization; positive regulation of mitochondrial fission; and positive regulation of protein targeting to membrane. Predicted to be located in membrane and mitochondrion. Predicted to be active in mitochondrial outer membrane and peroxisome. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human MFF (mitochondrial fission factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:5082098 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| encephalopathy due to defective mitochondrial and peroxisomal fission 2 | Alliance | Encephalopathy due to defective mitochondrial and peroxisomal fission 2 | 617086 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Mff-like domain | Mff/Tango-11 |
|---|---|---|---|
|
UniProtKB:A0A8M2BIG1
|
286 | ||
|
UniProtKB:Q503U3
|
275 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
zgc:110130-202
(1)
|
Ensembl | 1,554 nt | ||
| ncRNA |
zgc:110130-002
(1)
|
Ensembl | 790 nt |
Interactions and Pathways
No data available
Plasmids
No data available