Gene

alkbh1

ID

ZDB-GENE-050522-196

Name

alkB homolog 1, histone H2A dioxygenase

Symbol

alkbh1 Nomenclature History

Previous Names

si:ch211-133l14.1
zgc:112365

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable broad specificity oxidative DNA demethylase activity; ferrous iron binding activity; and oxidative RNA demethylase activity. Predicted to be involved in oxidative RNA demethylation. Predicted to act upstream of or within DNA repair. Predicted to be active in cytoplasm and nucleus. Orthologous to human ALKBH1 (alkB homolog 1, histone H2A dioxygenase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:112365 (1 image)
IMAGE:7156480 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With alkbh1 Human Ortholog

No data available

Associated With alkbh1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005123	Oxoglutarate/iron-dependent dioxygenase domain
Domain	IPR027450	Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Family	IPR004574	Alkylated DNA repair protein AlkB
Homologous_superfamily	IPR037151	Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Alkylated DNA repair protein AlkB	Alpha-ketoglutarate-dependent dioxygenase AlkB-like	Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily	Oxoglutarate/iron-dependent dioxygenase domain
UniProtKB:A0A8M2B5M4	InterPro	329
UniProtKB:Q502A8	InterPro	363

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
aberrant processed transcript	alkbh1-202 (1) Ensembl	Ensembl		1,032 nt	Select Tool ZFIN BLAST
mRNA	alkbh1-201 (1) Ensembl	Ensembl		1,214 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations