Gene
gsr
- ID
- ZDB-GENE-050522-116
- Name
- glutathione reductase
- Symbol
- gsr Nomenclature History
- Previous Names
-
- zgc:110010 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable flavin adenine dinucleotide binding activity and glutathione-disulfide reductase (NADPH) activity. Acts upstream of or within cell redox homeostasis. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Is expressed in intestinal bulb; liver; and macrophage. Human ortholog(s) of this gene implicated in cataract; congenital nonspherocytic hemolytic anemia 10; and macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110010 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nonspherocytic hemolytic anemia 10 | Alliance | Anemia, congenital, nonspherocytic hemolytic, 10, glutathione reductase deficient | 618660 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR012999 | Pyridine nucleotide-disulphide oxidoreductase, class I, active site |
| Domain | IPR004099 | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain |
| Domain | IPR023753 | FAD/NAD(P)-binding domain |
| Family | IPR001100 | Pyridine nucleotide-disulphide oxidoreductase, class I |
| Family | IPR006322 | Glutathione reductase, eukaryote/bacterial |
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Domain Details Per Protein
| Protein | Length | FAD/NAD-linked reductase, dimerisation domain superfamily | FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain superfamily | Glutathione reductase, eukaryote/bacterial | Glutathione reductase/thioredoxin reductase-like | Pyridine nucleotide-disulphide oxidoreductase, class I | Pyridine nucleotide-disulphide oxidoreductase, class I, active site | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q503Y5
|
425 | ||||||||
|
UniProtKB:A0A8M6Z2M1
|
500 | ||||||||
|
UniProtKB:A0A8M9QB21
|
469 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgFOS(gsr:EGFP) |
|
| 1 | Poon et al., 2017 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-127L12 | ZFIN Curated Data | |
| Contained in | BAC | CH211-195B11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110010 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192656 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020554 (1) | 2000 nt | ||
| Genomic | GenBank:BX005218 (1) | 183670 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z2M1 (1) | 500 aa |
- Park, K.H., Makki, H.M.M., Kim, S.H., Chung, H.J., Jung, J. (2023) Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 166:115350115350
- Qin, M.C., Li, J.J., Zheng, Y.T., Li, Y.J., Zhang, Y.X., Ou, R.X., He, W.Y., Zhao, J.M., Liu, S.T., Liu, M.H., Lin, H.Y., Gao, L. (2023) Naringin ameliorates liver fibrosis in zebrafish by modulating IDO1-mediated lipid metabolism and inflammatory infiltration. Food & function. 14(23):10347-10361
- Hari Deva Muthu, B., Manjunathan, T., Guru, A., Kumar, R.S., Rajakrishnan, R., Kuppusamy, P., Juliet, A., Gopinath, P., Arockiaraj, J. (2022) Hydroxyl containing benzo[b]thiophene analogs mitigates the acrylamide induced oxidative stress in the zebrafish larvae by stabilizing the glutathione redox cycle. Life sciences. 298:120507
- Haridevamuthu, B., Manjunathan, T., Guru, A., Ranjith Wilson Alphonse, C., Boopathi, S., Murugan, R., Gatasheh, M.K., Atef Hatamleh, A., Juliet, A., Gopinath, P., Arockiaraj, J. (2022) Amelioration of acrylamide induced neurotoxicity by benzo[b]thiophene analogs via glutathione redox dynamics in zebrafish larvae. Brain research. 1788:147941
- Li, C., Wu, Y., Li, H., Wang, H., Liu, J.X. (2022) Lipid-related metabolism during zebrafish embryogenesis under unbalanced copper homeostasis. Fish physiology and biochemistry. 48(6):1571-1586
- Song, L., Li, M., Feng, C., Sa, R., Hu, X., Wang, J., Yin, X., Qi, C., Dong, W., Yang, J. (2022) Protective effect of curcumin on zebrafish liver under ethanol-induced oxidative stress. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 258:109360
- Aksakal, E., Ekinci, D., Supuran, C.T. (2021) Dietary inclusion of royal jelly modulates gene expression and activity of oxidative stress enzymes in zebrafish. Journal of enzyme inhibition and medicinal chemistry. 36:885-894
- Ding, Y., Li, Y., Zhao, Z., Cliff Zhang, Q., Liu, F. (2021) The chromatin-remodeling enzyme Smarca5 regulates erythrocyte aggregation via Keap1-Nrf2 signaling. eLIFE. 10:
- Godoi, F.G.A., Forner-Piquer, I., Randazzo, B., Habibi, H.R., Lo Nostro, F.L., Moreira, R.G., Carnevali, O. (2021) Effects of Di-Isononyl Phthalate (DiNP) on Follicular Atresia in Zebrafish Ovary. Frontiers in endocrinology. 12:677853
- Park, K.H., Gooz, M., Ye, Z.W., Zhang, J., Beeson, G.C., Rockey, D.C., Kim, S.H. (2021) Flavin Adenine Dinucleotide Depletion Caused by electron transfer flavoprotein subunit alpha Haploinsufficiency Leads to Hepatic Steatosis and Injury in Zebrafish. Hepatology communications. 5:976-991
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