Gene
orai1b
- ID
- ZDB-GENE-050522-100
- Name
- ORAI calcium release-activated calcium modulator 1b
- Symbol
- orai1b Nomenclature History
- Previous Names
-
- orai1
- im:7146264
- zgc:109721
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have store-operated calcium channel activity. Involved in sarcomere organization. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease and tubular aggregate myopathy. Is expressed in brain; heart; liver; and myotome. Orthologous to human ORAI1 (ORAI calcium release-activated calcium modulator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7146264 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Völkers et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 9 | Alliance | Immunodeficiency 9 | 612782 |
| tubular aggregate myopathy 2 | Alliance | Myopathy, tubular aggregate, 2 | 615883 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Calcium release-activated calcium channel protein | Orai superfamily |
|---|---|---|---|
|
UniProtKB:A0A0R4I9A7
|
222 | ||
|
UniProtKB:Q6TLE6
|
222 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
orai1b-201
(1)
|
Havana | 1299 nt |
Interactions and Pathways
No data available
Plasmids
No data available