ZFIN ID: ZDB-GENE-050517-20
Gene Name: cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Gene Symbol: cftr
Previous Names: abcc7 (1), si:dkey-270i2.2 (1)
Location: Chr: 18   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
  enterocyte apical plasma membrane, enterocyte microvillus, gut epithelium apical surface, intestine (all 11) expand
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 14 genotypes
Alleles: pd1048, pd1049, pd1050, sa23289
Knockdown reagents: MO1-cftr (1), MO2-cftr (1), MO3-cftr (1), TALEN1-cftr (1)
PHENOTYPE
Data: 4 figures from 2 publications
Observed in: determination of heart left/right asymmetry, determination of left/right symmetry, determination of liver left/right asymmetry, heart (all 9) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Congenital bilateral absence of vas deferens 277180
Cystic fibrosis 219700
Sweat chloride elevation without CF
{Bronchiectasis with or without elevated sweat chloride 1, modifier of} 211400
{Hypertrypsinemia, neonatal}
{Pancreatitis, idiopathic} 167800
GENE ONTOLOGY
Ontology GO Term
Biological Process Kupffer's vesicle development (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001140 (1)
  • InterPro:IPR003439 (1)
  • InterPro:IPR003593 (1)
  • InterPro:IPR005291 (1)
  • InterPro:IPR009147 (1)
  • InterPro:IPR011527 (1)
  • InterPro:IPR017871 (1)
  • InterPro:IPR025837 (1)
  • InterPro:IPR027417 (1)
  • PROSITE:PS00211 (1)
  • PROSITE:PS50893 (1)
  • PROSITE:PS50929 (1)
  • Pfam:PF00005 (1)
  • Pfam:PF00664 (1)
  • Pfam:PF14396 (1)
  • EC:3.6.3.49 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cftr-001 (1) 4814
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-cftr (1)
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM cftr
    TgBAC(cftr-GFP), TgBAC(cftr-RFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    cftr Contained in: [BAC] DKEY-270I2 (1)
    cftr Encodes: [cDNA] MGC:198381 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001044883 (1) 4458 bp
    Genomic GenBank:BX470130 (1) 191401 bp
    Select Tool
    Polypeptide UniProtKB:B7ZVN9 (1) 1485 aa
    Sequence Clusters UniGene:74099 (1)
    Sequence Information (all 12)
    OTHER cftr GENE PAGES
  • Gene:559080 (1)
  • VEGA:OTTDARG00000013769 (1)
  • Ensembl(Zv9):ENSDARG00000041107 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish cftr 18  
    Human CFTR 7 (7q31.2)
  • OMIM:602421
  • Gene:1080
  • Mouse Cftr 6 ( 8.10 cM)
  • MGI:88388
  • Gene:12638
  • Orthology Details
    CITATIONS (24)