ZFIN ID: ZDB-GENE-050517-20
Gene Name: cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Gene Symbol: cftr
Previous Names: abcc7 (1), si:dkey-270i2.2 (1)
Location: Chr: 18 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 6 figures from 5 publications
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
  enterocyte apical plasma membrane, enterocyte microvillus, floor plate, gut epithelium apical surface (all 15) expand
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Allele Type Mutagen Suppliers
pd1048 Indel TALEN
pd1049 Indel TALEN
pd1050 Indel TALEN
sa23289 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-cftr (1), MO2-cftr (1), MO3-cftr (1), MO4-cftr (1), MO5-cftr (1) (all 6) expand
    PHENOTYPE
    Data: 9 figures from 4 publications
    Observed in: determination of heart left/right asymmetry, determination of left/right symmetry, determination of liver left/right asymmetry, exocrine pancreas central region (all 19) expand
    DISEASE ASSOCIATED WITH cftr HUMAN ORTHOLOG 
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    bronchiectasis {Bronchiectasis with or without elevated sweat chloride 1, modifier of} 211400
    cystic fibrosis Cystic fibrosis 219700
    {Pancreatitis, idiopathic} 167800
    {Hypertrypsinemia, neonatal}
    Congenital bilateral absence of vas deferens 277180
    Sweat chloride elevation without CF
    GENE ONTOLOGY 
    Ontology GO Term
    Biological Process Kupffer's vesicle development (more)
    Cellular Component apical plasma membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003439 (1)
  • InterPro:IPR003593 (1)
  • InterPro:IPR009147 (1)
  • InterPro:IPR011527 (1)
  • InterPro:IPR017871 (1)
  • InterPro:IPR025837 (1)
  • InterPro:IPR027417 (1)
  • PROSITE:PS00211 (1)
  • PROSITE:PS50893 (1)
  • PROSITE:PS50929 (1)
  • Pfam:PF00005 (1)
  • Pfam:PF00664 (1)
  • Pfam:PF14396 (1)
  • EC:3.6.3.49 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cftr-001 (1) 4814
    GENE PRODUCT DESCRIPTION
    ANTIBODIES 
    Ab1-cftr (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cftr
    TgBAC(cftr-GFP), TgBAC(cftr-RFP), TgBAC(cftr:GAL4)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    cftrContained in: [BAC] DKEY-270I2 (1) (order this)
    cftrEncodes: [cDNA] MGC:198381 (1) (order this)
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001044883 (1) 4458bp
    Genomic GenBank:BX470130 (1) 191401bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4ID63 (1) 1487aa
    Sequence Clusters UniGene:74099 (1)
    Sequence Information (all 13)
    OTHER cftr GENE PAGES 
  • Gene:559080 (1)
  • VEGA:OTTDARG00000013769 (1)
  • Ensembl(GRCz10):ENSDARG00000041107 (1)
  • ORTHOLOGY for cftr (Chr: 18) 
    Species Symbol Chromosome Accession # Evidence
    Human CFTR 7
  • Gene:1080
  • OMIM:602421
  • HGNC:1884
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Mouse Cftr 6
  • MGI:88388
  • Gene:12638
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (30)