ZFIN ID: ZDB-GENE-050517-20
Gene Name: cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Gene Symbol: cftr
Previous Names: abcc7 (1), si:dkey-270i2.2 (1)
Location: Chr: 18   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 5 figures from 4 publications
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
  enterocyte apical plasma membrane, enterocyte microvillus, gut epithelium apical surface, intestine (all 13) expand
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 18 Genotypes
Knockdown reagents: MO1-cftr (1), MO2-cftr (1), MO3-cftr (1), TALEN1-cftr (1)

Allele Type Mutagen Suppliers
pd1048 Indel TALEN
pd1049 Indel TALEN
pd1050 Indel TALEN
sa23289 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE
    Data: 7 figures from 3 publications
    Observed in: determination of heart left/right asymmetry, determination of left/right symmetry, determination of liver left/right asymmetry, exocrine pancreas (all 16) expand
    DISEASE ASSOCIATED WITH cftr HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    cystic fibrosis Cystic fibrosis 219700
    bronchiectasis {Bronchiectasis with or without elevated sweat chloride 1, modifier of} 211400
    Congenital bilateral absence of vas deferens 277180
    {Pancreatitis, idiopathic} 167800
    Sweat chloride elevation without CF
    {Hypertrypsinemia, neonatal}
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process Kupffer's vesicle development (more)
    Cellular Component chloride channel complex (more)
    Molecular Function ATP binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003439 (1)
  • InterPro:IPR003593 (1)
  • InterPro:IPR009147 (1)
  • InterPro:IPR011527 (1)
  • InterPro:IPR017871 (1)
  • InterPro:IPR025837 (1)
  • InterPro:IPR027417 (1)
  • PROSITE:PS00211 (1)
  • PROSITE:PS50893 (1)
  • PROSITE:PS50929 (1)
  • Pfam:PF00005 (1)
  • Pfam:PF00664 (1)
  • Pfam:PF14396 (1)
  • EC:3.6.3.49 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cftr-001 (1) 4814
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-cftr (1)
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM cftr
    TgBAC(cftr-GFP), TgBAC(cftr-RFP), TgBAC(cftr:GAL4)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    cftr Contained in: [BAC] DKEY-270I2 (1) (order this)
    cftr Encodes: [cDNA] MGC:198381 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001044883 (1) 4458 bp
    Genomic GenBank:BX470130 (1) 191401 bp
    Select Tool
    Polypeptide UniProtKB:B7ZVN9 (1) 1485 aa
    Sequence Clusters UniGene:74099 (1)
    Sequence Information (all 12)
    OTHER cftr GENE PAGES
  • Gene:559080 (1)
  • VEGA:OTTDARG00000013769 (1)
  • Ensembl(Zv9):ENSDARG00000041107 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish cftr 18  
    Human CFTR 7 (7q31.2)
  • OMIM:602421
  • Gene:1080
  • Mouse Cftr 6 ( 8.10 cM)
  • MGI:88388
  • Gene:12638
  • Orthology Details
    CITATIONS (26)