ZFIN ID: ZDB-GENE-050517-20
Gene Name: cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Gene Symbol: cftr
Previous Names: abcc7 (1), si:dkey-270i2.2 (1)
Location: Chr: 18 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 6 figures from 5 publications
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
  enterocyte apical plasma membrane, enterocyte microvillus, floor plate, gut epithelium apical surface (all 15) expand
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
pd1048 Indel Unknown Unknown TALEN
pd1049 Indel Unknown Frameshift, Premature Stop TALEN
pd1050 Indel Unknown Premature Stop TALEN
sa23289 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-cftr (1), MO2-cftr (1), MO3-cftr (1), MO4-cftr (1), MO5-cftr (1) (all 6) expand
    PHENOTYPE
    Data: 9 figures from 4 publications
    Observed in: determination of heart left/right asymmetry, determination of left/right symmetry, determination of liver left/right asymmetry, exocrine pancreas central region (all 19) expand
    DISEASE ASSOCIATED WITH cftr HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    bronchiectasis {Bronchiectasis with or without elevated sweat chloride 1, modifier of} 211400
    cystic fibrosis Cystic fibrosis 219700
    Congenital bilateral absence of vas deferens 277180
    {Pancreatitis, idiopathic} 167800
    {Hypertrypsinemia, neonatal}
    Sweat chloride elevation without CF
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process Kupffer's vesicle development (more)
    Cellular Component apical plasma membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003439 (1)
  • InterPro:IPR003593 (1)
  • InterPro:IPR009147 (1)
  • InterPro:IPR011527 (1)
  • InterPro:IPR017871 (1)
  • InterPro:IPR025837 (1)
  • InterPro:IPR027417 (1)
  • PROSITE:PS00211 (1)
  • PROSITE:PS50893 (1)
  • PROSITE:PS50929 (1)
  • Pfam:PF00005 (1)
  • Pfam:PF00664 (1)
  • Pfam:PF14396 (1)
  • EC:3.6.3.49 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cftr-001 (1) 4814
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIES
    Ab1-cftr (1)
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM cftr
    TgBAC(cftr-GFP), TgBAC(cftr-RFP), TgBAC(cftr:GAL4)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    cftrContained in: [BAC] DKEY-270I2 (1) (order this)
    cftrEncodes: [cDNA] MGC:198381 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001044883 (1) 4458bp
    Genomic GenBank:BX470130 (1) 191401bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4ID63 (1) 1487aa
    Sequence Clusters UniGene:74099 (1)
    Sequence Information (all 13)
    OTHER cftr GENE PAGES
  • Gene:559080 (1)
  • VEGA:OTTDARG00000013769 (1)
  • Ensembl(GRCz10):ENSDARG00000041107 (1)
  • ORTHOLOGY for cftr (Chr: 18)
    Species Symbol Chromosome Accession # Evidence
    Human CFTR 7
  • Gene:1080
  • OMIM:602421
  • HGNC:1884
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Mouse Cftr 6
  • MGI:88388
  • Gene:12638
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (31)