Gene
gipr
- ID
- ZDB-GENE-050516-4
- Name
- gastric inhibitory polypeptide receptor
- Symbol
- gipr Nomenclature History
- Previous Names
-
- si:ch211-188j1.2
- zgcg-r1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled peptide receptor activity; gastric inhibitory peptide receptor activity; and peptide hormone binding activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cardiovascular system disease; diabetes mellitus; obesity; and type 2 diabetes mellitus. Orthologous to human GIPR (gastric inhibitory polypeptide receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from O'Hare et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa22664 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22665 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa30995 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39053 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017983 | GPCR, family 2, secretin-like, conserved site |
| Domain | IPR001879 | GPCR, family 2, extracellular hormone receptor domain |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Family | IPR000832 | GPCR, family 2, secretin-like |
| Family | IPR001749 | GPCR, family 2, gastric inhibitory polypeptide receptor |
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Domain Details Per Protein
| Protein | Length | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2, gastric inhibitory polypeptide receptor | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPCR, family 2, secretin-like, conserved site | G-protein coupled receptor 2 |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9NYP1
|
270 | |||||||
|
UniProtKB:X1WDQ9
|
499 | |||||||
|
UniProtKB:E7FCX8
|
514 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-188J1 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005157739 (1) | 7409 nt | ||
| Genomic | GenBank:CR388133 (2) | 98273 nt | ||
| Polypeptide | UniProtKB:E7FCX8 (1) | 514 aa |
- Comparative Orthology
- Alliance
- Du, Q., Shao, R., Wang, W., Zhang, H., Liao, X., Wang, Z., Yin, Z., Ai, Q., Mai, K., Tang, X., Wan, M. (2024) Vitamin D3 Regulates Energy Homeostasis under Short-Term Fasting Condition in Zebrafish (Danio Rerio). Nutrients. 16(9):
- O'Hare, E.A., Yerges-Armstrong, L.M., Perry, J.A., Shuldiner, A.R., Zaghloul, N.A. (2016) Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. Molecular endocrinology (Baltimore, Md.). 30(4):429-45
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- On, J.S.W., Duan, C., Lee, L.T.O. (2015) Functional pairing of class B1 ligand-GPCR in cephalochordate provides evidence of the origin of PTH and PACAP/glucagonreceptor family. Molecular Biology and Evolution. 32(8):2048-59
- Park, C.R., Moon, M.J., Park, S., Kim, D.K., Cho, E.B., Millar, R.P., Hwang, J.I., and Seong, J.Y. (2013) A Novel Glucagon-Related Peptide (GCRP) and Its Receptor GCRPR Account for Coevolution of Their Family Members in Vertebrates. PLoS One. 8(6):e65420
- Cruz, S.A., Tseng, Y.C., Kaiya, H., Hwang, P.P., Cruz, S.A., Hwang, P.P., Kaiya, H., Tseng, Y.C., and Hwang, P.P. (2010) Ghrelin affects carbohydrate-glycogen metabolism via insulin inhibition and glucagon stimulation in the zebrafish (Danio rerio) brain. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 156(2):190-200
- Irwin, D.M., and Wong, K. (2005) Evolution of New Hormone Function: Loss and Gain of a Receptor. The Journal of heredity. 96(3):205-211
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