Gene

dctn1b

ID

ZDB-GENE-050419-28

Name

dynactin 1b

Symbol

dctn1b Nomenclature History

Previous Names

mok2 (1)
si:ch211-132e22.1

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have microtubule binding activity. Involved in camera-type eye photoreceptor cell differentiation. Predicted to localize to centrosome. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Is expressed in anterior lateral line ganglion; brain; and posterior lateral line ganglion. Orthologous to human DCTN1 (dynactin subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Atkins et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dctn1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
amyotrophic lateral sclerosis type 1	Alliance	{Amyotrophic lateral sclerosis, susceptibility to}	105400
autosomal dominant distal hereditary motor neuronopathy 14	Alliance	Neuronopathy, distal hereditary motor, autosomal dominant 14	607641
Perry syndrome	Alliance	Perry syndrome	168605

Associated With dctn1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000938	CAP Gly-rich domain
Domain	IPR022157	Dynein associated protein
Homologous_superfamily	IPR036859	CAP Gly-rich domain superfamily

Domain Details Per Protein

Protein	Length	CAP Gly-rich domain	CAP Gly-rich domain superfamily	Dynein associated protein
UniProtKB:A0A8M9QK32 InterPro	1257
UniProtKB:A0A8M3BEJ1 InterPro	1260
UniProtKB:A0A8M3AYX5 InterPro	1258
UniProtKB:A0A8M9QNN7 InterPro	1263
UniProtKB:A0A8M3B7W5 InterPro	1251
UniProtKB:A0A8M9QFT7 InterPro	1264
UniProtKB:A0A8M3B541 InterPro	1245

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	dctn1b-201 (1) Ensembl	Ensembl		8,610 nt	Select Tool
mRNA	dctn1b-202 (1) Ensembl	Ensembl		3,588 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations