Gene
chd2
- ID
- ZDB-GENE-050419-256
- Name
- chromodomain helicase DNA binding protein 2
- Symbol
- chd2 Nomenclature History
- Previous Names
-
- si:ch211-196l7.5
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity. Involved in chordate embryonic development and locomotion. Predicted to localize to nucleus. Used to study childhood onset epileptic encephalopathy. Human ortholog(s) of this gene implicated in childhood onset epileptic encephalopathy. Orthologous to human CHD2 (chromodomain helicase DNA binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158683 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 94 | Alliance | Developmental and epileptic encephalopathy 94 | 615369 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| myoclonic-atonic epilepsy | WT + MO1-chd2 | standard conditions | Suls et al., 2013 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023779 | Chromo domain, conserved site |
| Domain | IPR000330 | SNF2, N-terminal |
| Domain | IPR000953 | Chromo/chromo shadow domain |
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR023780 | Chromo domain |
| Domain | IPR025260 | Chromodomain-helicase-DNA-binding protein 1-like, C-terminal domain |
| Domain | IPR040793 | CDH1/2, SANT-Helical linker 1 |
| Domain | IPR049730 | SNF2/RAD5-like, C-terminal helicase domain |
| Homologous_superfamily | IPR016197 | Chromo-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR038718 | SNF2-like, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | CDH1/2, SANT-Helical linker 1 | Chromo/chromo shadow domain | Chromo domain | Chromo domain, conserved site | Chromodomain-helicase-DNA-binding protein 1-like, C-terminal domain | Chromo-like domain superfamily | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | SNF2-like, N-terminal domain superfamily | SNF2, N-terminal | SNF2/RAD5-like, C-terminal helicase domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IR86
|
1799 | ||||||||||||
|
UniProtKB:A0A8M9PQC3
|
1817 | ||||||||||||
|
UniProtKB:A0A8M9P155
|
1778 | ||||||||||||
|
UniProtKB:A0A8M3AUW8
|
1813 |
Interactions and Pathways
No data available
Plasmids
No data available