Gene

hrasa

ID

ZDB-GENE-050417-95

Name

HRas proto-oncogene, GTPase a

Symbol

hrasa Nomenclature History

Previous Names

hras
xRAS1 (1)
sb:eu826
zgc:110250 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in basal plate midbrain region; nervous system; and trigeminal placode. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:110250 (9 images)
eu826 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hrasa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Costello syndrome	Alliance	Congenital myopathy with excess of muscle spindles	218040
Costello syndrome	Alliance	Costello syndrome	218040
epidermal nevus	Alliance	Nevus sebaceous or woolly hair nevus, somatic	162900
follicular thyroid carcinoma	Alliance	Thyroid carcinoma, follicular, somatic	188470
large congenital melanocytic nevus	Alliance	Spitz nevus or nevus spilus, somatic	137550
linear nevus sebaceous syndrome	Alliance	Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic	163200
urinary bladder cancer	Alliance	Bladder cancer, somatic	109800

Associated With hrasa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005225	Small GTP-binding domain
Family	IPR001806	Small GTPase
Family	IPR020849	Small GTPase, Ras-type
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase