Gene
gtdc1
- ID
- ZDB-GENE-050417-8
- Name
- glycosyltransferase-like domain containing 1
- Symbol
- gtdc1 Nomenclature History
- Previous Names
-
- zgc:110568
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable tRNA-queuosine(34) beta-mannosyltransferase activity. Acts upstream of or within central nervous system development. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human GTDC1 (glycosyltransferase like domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158892 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Aksoy et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a374 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| la026849Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9220 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa10288 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34657 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zf3915 | Allele with one insertion | Exon 4 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gtdc1 | Thyme et al., 2019 | |
| CRISPR2-gtdc1 | Thyme et al., 2019 | |
| CRISPR3-gtdc1 | Thyme et al., 2019 | |
| CRISPR4-gtdc1 | Thyme et al., 2019 | |
| CRISPR5-gtdc1 | Zhao et al., 2023 | |
| MO1-gtdc1 | N/A | Aksoy et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Glycosyl transferase, family 1 | Glycosyltransferase-like domain-containing protein 1 | tRNA-queuosine alpha-mannosyltransferase, N-terminal |
|---|---|---|---|---|
|
UniProtKB:A0A8M9QAN7
|
433 | |||
|
UniProtKB:Q568B7
|
433 | |||
|
UniProtKB:A0A8M6Z8E3
|
432 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-69N2 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-28L22 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-52O2 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7158892 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:110568 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001017560 (1) | 1512 nt | ||
| Genomic | GenBank:CR405716 (2) | 202532 nt | ||
| Polypeptide | UniProtKB:A0A8M9QAN7 (1) | 433 aa |
- Zhao, X., Ma, D., Ishiguro, K., Saito, H., Akichika, S., Matsuzawa, I., Mito, M., Irie, T., Ishibashi, K., Wakabayashi, K., Sakaguchi, Y., Yokoyama, T., Mishima, Y., Shirouzu, M., Iwasaki, S., Suzuki, T., Suzuki, T. (2023) Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Cell. 186(25):5517-5535.e24
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Aksoy, I., Utami, K.H., Winata, C.L., Hillmer, A.M., Rouam, S.L., Briault, S., Davila, S., Stanton, L.W., Cacheux, V. (2017) Personalized genome sequencing coupled with iPSC technology identifies GTDC1 as a gene involved in neurodevelopmental disorders. Human molecular genetics. 26:367-382
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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