Gene
entpd6
- ID
- ZDB-GENE-050417-412
- Name
- ectonucleoside triphosphate diphosphohydrolase 6
- Symbol
- entpd6 Nomenclature History
- Previous Names
-
- NTPDase6 (1)
- zgc:110701
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity and nucleoside diphosphate phosphatase activity. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in brain; heart; and liver. Orthologous to human ENTPD6 (ectonucleoside triphosphate diphosphohydrolase 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Rosemberg et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa18584 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR000407 | Nucleoside phosphatase GDA1/CD39 |
Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleoside phosphatase GDA1/CD39 |
|---|---|---|---|
| UniProtKB:A0A8M3AR88 | InterPro | 441 | |
| UniProtKB:Q567W7 | InterPro | 442 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
entpd6-201
(1)
|
Ensembl | 1,677 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-67N1 | ZFIN Curated Data | |
| Encodes | EST | wz10865 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110701 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001017862 (1) | 1641 nt | ||
| Genomic | GenBank:AL929290 (1) | 168517 nt | ||
| Polypeptide | UniProtKB:Q567W7 (1) | 442 aa |
- Tsai, I.C., Adams, K.A., Tzeng, J.A., Shennib, O., Tan, P.L., Katsanis, N. (2019) Genome-wide suppressor screen identifies USP35/USP38 as therapeutic candidates for ciliopathies. JCI insight. 4(22):
- Rosemberg, D.B., Rico, E.P., Langoni, A.S., Spinelli, J.T., Pereira, T.C., Dias, R.D., Souza, D.O., Bonan, C.D., and Bogo, M.R. (2010) NTPDase family in zebrafish: Nucleotide hydrolysis, molecular identification and gene expression profiles in brain, liver and heart. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 155(3):230-240
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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