Gene
nfu1
- ID
- ZDB-GENE-050417-365
- Name
- NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
- Symbol
- nfu1 Nomenclature History
- Previous Names
-
- HIRA interacting protein 5
- hirip5 (1)
- zgc:109711
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to be involved in protein maturation. Predicted to act upstream of or within iron-sulfur cluster assembly. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 1. Orthologous to human NFU1 (NFU1 iron-sulfur cluster scaffold).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109711 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa38712 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 1 of 1
Show
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| multiple mitochondrial dysfunctions syndrome 1 | Alliance | Multiple mitochondrial dysfunctions syndrome 1 | 605711 |
| Spastic paraplegia 93, autosomal recessive | 620938 |
1 - 2 of 2
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001075 | NIF system FeS cluster assembly, NifU, C-terminal |
| Domain | IPR014824 | Scaffold protein Nfu/NifU, N-terminal |
| Family | IPR035433 | NFU1-like |
| Homologous_superfamily | IPR034904 | Fe-S cluster assembly domain superfamily |
| Homologous_superfamily | IPR036498 | Scaffold protein Nfu/NifU, N-terminal domain superfamily |
1 - 5 of 5
Domain Details Per Protein
| Protein | Additional Resources | Length | Fe-S cluster assembly domain superfamily | NFU1-like | NIF system FeS cluster assembly, NifU, C-terminal | Scaffold protein Nfu/NifU, N-terminal | Scaffold protein Nfu/NifU, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:B0S8L0 | InterPro | 243 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-120B19 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109711 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173664 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192272 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001122708 (1) | 1651 nt | ||
| Genomic | GenBank:BX957316 (1) | 144967 nt | ||
| Polypeptide | UniProtKB:B0S8L0 (1) | 243 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Hugo, S.E., Schlegel, A. (2017) A genetic model to study increased hexosamine biosynthetic flux. Endocrinology. 158(8):2420-2426
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Harden, M.V., Newton, L.A., Lloyd, R.C., Whitlock, K.E. (2006) Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish. Journal of neurobiology. 66(13):1452-1466
- Steinke, D., Salzburger, W., Braasch, I., and Meyer, A. (2006) Many genes in fish have species-specific asymmetric rates of molecular evolution. BMC Genomics. 7(1):20
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 6 of 6
Show