Gene
glb1
- ID
- ZDB-GENE-050410-9
- Name
- galactosidase, beta 1
- Symbol
- glb1 Nomenclature History
- Previous Names
-
- zgc:110823
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Exhibits beta-galactosidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to localize to vacuole. Human ortholog(s) of this gene implicated in GM1 gangliosidosis (multiple) and mucopolysaccharidosis IV (multiple). Orthologous to human GLB1 (galactosidase beta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110823 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| GM1 gangliosidosis type 1 | Alliance | GM1-gangliosidosis, type I | 230500 |
| GM1 gangliosidosis type 2 | Alliance | GM1-gangliosidosis, type II | 230600 |
| GM1 gangliosidosis type 3 | Alliance | GM1-gangliosidosis, type III | 230650 |
| mucopolysaccharidosis type IVB | Alliance | Mucopolysaccharidosis type IVB (Morquio) | 253010 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019801 | Glycoside hydrolase, family 35, conserved site |
| Domain | IPR031330 | Glycoside hydrolase 35, catalytic domain |
| Domain | IPR048912 | Beta-galactosidase 1-like , first all-beta domain |
| Domain | IPR048913 | Beta-galactosidase, galactose-binding domain |
| Family | IPR001944 | Glycoside hydrolase, family 35 |
| Family | IPR026283 | Beta-galactosidase 1-like |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
| Homologous_superfamily | IPR017853 | Glycoside hydrolase superfamily |
Domain Details Per Protein
| Protein | Length | Beta-galactosidase 1-like | Beta-galactosidase 1-like , first all-beta domain | Beta-galactosidase, galactose-binding domain | Galactose-binding-like domain superfamily | Glycoside hydrolase 35, catalytic domain | Glycoside hydrolase, family 35 | Glycoside hydrolase, family 35, conserved site | Glycoside hydrolase superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B6W2
|
676 | ||||||||
|
UniProtKB:Q56A50
|
651 |
Interactions and Pathways
No data available
Plasmids
No data available