Gene
nsd3
- ID
- ZDB-GENE-050324-2
- Name
- nuclear receptor binding SET domain protein 3
- Symbol
- nsd3 Nomenclature History
- Previous Names
-
- whsc1l1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable histone H3K36 methyltransferase activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within chromatin organization and methylation. Predicted to be located in chromosome. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in myeloid leukemia. Orthologous to human NSD3 (nuclear receptor binding SET domain protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sun et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR000313 | PWWP domain |
| Domain | IPR001214 | SET domain |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR003616 | Post-SET domain |
| Domain | IPR006560 | AWS domain |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR041306 | NSD, Cys-His rich domain |
| Domain | IPR047451 | Histone-lysine N-methyltransferase NSD3, first PWWP domain |
| Domain | IPR047453 | Histone-lysine N-methyltransferase NSD3, second PWWP domain |
| Domain | IPR047458 | Histone-lysine N-methyltransferase NSD3, fourth PHD finger |
| Domain | IPR047527 | Histone-lysine N-methyltransferase NSD3, fifth PHD finger |
| Family | IPR050777 | SET2 Histone-Lysine N-Methyltransferase |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Length | AWS domain | Histone-lysine N-methyltransferase NSD3, fifth PHD finger | Histone-lysine N-methyltransferase NSD3, first PWWP domain | Histone-lysine N-methyltransferase NSD3, fourth PHD finger | Histone-lysine N-methyltransferase NSD3, second PWWP domain | NSD, Cys-His rich domain | Post-SET domain | PWWP domain | SET2 Histone-Lysine N-Methyltransferase | SET domain | SET domain superfamily | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B1N3
|
1563 | ||||||||||||||||
|
UniProtKB:A0A8M2B1H9
|
1521 | ||||||||||||||||
|
UniProtKB:F1QV68
|
1513 |
Interactions and Pathways
No data available
Plasmids
No data available