Gene

adcyap1r1a

ID

ZDB-GENE-050315-1

Name

adenylate cyclase activating polypeptide 1a (pituitary) receptor type I

Symbol

adcyap1r1a Nomenclature History

Previous Names

adcyap1r1
pac1
PAC1a-R (1)
PAC1B (1)
PAC1R (1)
PAC1 receptor (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have G protein-coupled peptide receptor activity and peptide hormone binding activity. Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway and phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to localize to integral component of membrane. Is expressed in several structures, including central nervous system; eye; gut; heart; and pleuroperitoneal region. Orthologous to human ADCYAP1R1 (ADCYAP receptor type I).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adcyap1r1a Human Ortholog

No data available

Associated With adcyap1r1a Via Experimental Models

Human Disease	Fish	Conditions	Citations
post-traumatic stress disorder	adcyap1r1a^wz18/wz18	standard conditions	Biran et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017983	GPCR, family 2, secretin-like, conserved site
Domain	IPR001879	GPCR, family 2, extracellular hormone receptor domain
Domain	IPR017981	GPCR, family 2-like, 7TM
Family	IPR000832	GPCR, family 2, secretin-like
Family	IPR002285	GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor
Homologous_superfamily	IPR036445	GPCR family 2, extracellular hormone receptor domain superfamily

Domain Details Per Protein

Protein	Length	GPCR, family 2, extracellular hormone receptor domain	GPCR family 2, extracellular hormone receptor domain superfamily	GPCR, family 2-like, 7TM	GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor	GPCR, family 2, secretin-like	GPCR, family 2, secretin-like, conserved site
UniProtKB:Q5C8U8 InterPro	478
UniProtKB:E7FF76 InterPro	445
UniProtKB:Q5C8U6 InterPro	479
UniProtKB:Q5C8V0 InterPro	451

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	adcyap1r1a-202 (1) Ensembl	Havana	1209 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	adcyap1r1a-201 (1) Ensembl	Havana	1102 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	adcyap1r1a-203 (1) Ensembl	Havana	9167 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	adcyap1r1a-204 (1) Ensembl	Havana	1186 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations