Gene
dscama
- ID
- ZDB-GENE-050310-7
- Name
- Down syndrome cell adhesion molecule a
- Symbol
- dscama Nomenclature History
- Previous Names
-
- dscam
- zDscam (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable cell-cell adhesion mediator activity. Acts upstream of or within cell migration involved in gastrulation and enteric nervous system development. Located in plasma membrane. Is expressed in intestinal bulb and nervous system. Orthologous to human DSCAM (DS cell adhesion molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lu et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa7221 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11007 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11753 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18994 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21791 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21792 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21793 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31795 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41717 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41718 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dscama | (2) | |
| CRISPR2-dscama | Gagnon et al., 2014 | |
| MO1-dscama | N/A | (2) |
| MO2-dscama | N/A | Yimlamai et al., 2005 |
| MO3-dscama | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Immunoglobulin V-set domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B246 | InterPro | 1515 | |||||||||
| UniProtKB:A0A8M9QGN7 | InterPro | 2025 | |||||||||
| UniProtKB:Q53CM6 | InterPro | 2024 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dscama-201
(1)
|
Ensembl | 7,164 nt | ||
| mRNA |
dscama-202
(1)
|
Ensembl | 6,036 nt | ||
| mRNA |
dscama-203
(1)
|
Ensembl | 6,267 nt | ||
| mRNA |
dscama-204
(1)
|
Ensembl | 6,081 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-231M12 | ||
| Contained in | BAC | CH211-284B10 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030224 (1) | 7164 nt | ||
| Genomic | GenBank:BX248386 (1) | 148681 nt | ||
| Polypeptide | UniProtKB:A0A8M9QGN7 (1) | 2025 aa |
- Lu, Y.J., Yu, W.W., Cui, M.M., Yu, X.X., Song, H.L., Bai, M.R., Wu, W.J., Gu, B.L., Wang, J., Cai, W., Chu, X. (2021) Association Analysis of Variants of DSCAM and BACE2 With Hirschsprung Disease Susceptibility in Han Chinese and Functional Evaluation in Zebrafish. Frontiers in cell and developmental biology. 9:641152
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Galicia, C.A., Sukeena, J.M., Stenkamp, D.L., Fuerst, P.G. (2018) Expression patterns of dscam and sdk gene paralogs in developing zebrafish retina.. Molecular Vision. 24:443-458
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Tu, H., Peng, T., Liu, J., Chen, X., Fan, C., Huang, Z., Zhang, Y., Zou, F., Meng, X. (2017) Role of neurexin2a in lead-induced locomotor defect in developing zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 194:167-175
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gagnon, J.A., Valen, E., Thyme, S.B., Huang, P., Ahkmetova, L., Pauli, A., Montague, T.G., Zimmerman, S., Richter, C., Schier, A.F. (2014) Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs. PLoS One. 9:e98186
- Hale, L.A., Fowler, D.K., and Eisen, J.S. (2011) Netrin Signaling Breaks the Equivalence between Two Identified Zebrafish Motoneurons Revealing a New Role of Intermediate Targets. PLoS One. 6(10):e25841
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Yimlamai, D., Konnikova, L., Moss, L.G., and Jay, D.G. (2005) The zebrafish down syndrome cell adhesion molecule is involved in cell movement during embryogenesis. Developmental Biology. 279(1):44-57
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