Gene
spen
- ID
- ZDB-GENE-050309-70
- Name
- spen family transcriptional repressor
- Symbol
- spen Nomenclature History
- Previous Names
-
- im:7148349 (1)
- si:ch211-125c5.1
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable mRNA binding activity. Acts upstream of or within heart contraction. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma. Orthologous to human SPEN (spen family transcriptional repressor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Rattka et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Radio-Tartaglia syndrome | 619312 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR010912 | Spen paralogue/orthologue C-terminal, metazoa |
| Domain | IPR012921 | Spen paralogue and orthologue SPOC, C-terminal |
| Domain | IPR034172 | SHARP, RNA recognition motif 1 |
| Domain | IPR034173 | SHARP, RNA recognition motif 2 |
| Domain | IPR034174 | SHARP, RNA recognition motif 3 |
| Domain | IPR034175 | SHARP, RNA recognition motif 4 |
| Domain | IPR049093 | Msx2-interacting protein, nuclear receptor-interacting domain |
| Domain | IPR049095 | Msx2-interacting protein, MID domain |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR016194 | SPOC-like, C-terminal domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Msx2-interacting protein, MID domain | Msx2-interacting protein, nuclear receptor-interacting domain | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain | SHARP, RNA recognition motif 1 | SHARP, RNA recognition motif 2 | SHARP, RNA recognition motif 3 | SHARP, RNA recognition motif 4 | Spen paralogue and orthologue SPOC, C-terminal | Spen paralogue/orthologue C-terminal, metazoa | SPOC-like, C-terminal domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PQS1
|
3476 | ||||||||||||
|
UniProtKB:A0A8M3AMZ8
|
3475 | ||||||||||||
|
UniProtKB:F1QMN6
|
3476 |
Interactions and Pathways
No data available
Plasmids
No data available