Gene
tmsb
- ID
- ZDB-GENE-050307-5
- Name
- thymosin, beta
- Symbol
- tmsb Nomenclature History
- Previous Names
-
- im:7149936
- zgc:136504
- zTB10 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable actin monomer binding activity. Acts upstream of or within induction of bacterial agglutination and regulation of inflammatory response to wounding. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in several structures, including gill; integument; liver; pleuroperitoneal region; and thymus. Orthologous to human TMSB10 (thymosin beta 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7149936 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Beta-thymosin | Beta-thymosin superfamily |
|---|---|---|---|
|
UniProtKB:Q9W7M8
|
45 | ||
|
UniProtKB:Q1RM34
|
45 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-123O7 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7149936 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:136504 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174787 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205581 (1) | 383 nt | ||
| Genomic | GenBank:CR354383 (2) | 168569 nt | ||
| Polypeptide | UniProtKB:Q1RM34 (1) | 45 aa |
No data available
- Lange, C., Rost, F., Machate, A., Reinhardt, S., Lesche, M., Weber, A., Kuscha, V., Dahl, A., Rulands, S., Brand, M. (2020) Single cell sequencing of radial glia progeny reveals diversity of newborn neurons in the adult zebrafish brain. Development (Cambridge, England). 147(1):
- Zou, S.S., Wang, J., Li, B.X., Yang, G.W., Sun, J.J., Yang, H.T. (2019) Thymosin participates in antimicrobial immunity in zebrafish. Fish & shellfish immunology. 87:371-378
- Murphy, P.J., Wu, S.F., James, C.R., Wike, C.L., Cairns, B.R. (2018) Placeholder Nucleosomes Underlie Germline-to-Embryo DNA Methylation Reprogramming. Cell. 172(5):993-1006.e13
- Ziegler, T., Hinkel, R., Stöhr, A., Eschenhagen, T., Laugwitz, K.L., le Noble, F., David, R., Hansen, A., Kupatt, C. (2017) Thymosin β4 Improves Differentiation and Vascularization of EHTs.. Stem Cells International. 2017:6848271
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Xiao, Z., Shen, J., Feng, H., Liu, H., Wang, Y., Huang, R., Guo, Q. (2015) Characterization of two thymosins as immune-related genes in common carp (cyprinus carpio l.). Developmental and comparative immunology. 50(1):29-37
- Aoki, M., Segawa, H., Naito, M., and Okamoto, H. (2014) Identification of possible downstream genes required for the extension of peripheral axons in primary sensory neurons. Biochemical and Biophysical Research Communications. 445(2):357-362
- Elsaeidi, F., Bemben, M.A., Zhao, X.F., and Goldman, D. (2014) Jak/Stat signaling stimulates zebrafish optic nerve regeneration and overcomes the inhibitory actions of Socs3 and Sfpq. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(7):2632-2644
- Shin, S.H., Lee, S., Bae, J.S., Jee, J.G., Cha, H.J., Lee, Y.M. (2014) Thymosin beta4 regulates cardiac valve formation via endothelial-mesenchymal transformation in zebrafish embryos. Molecules and cells. 37:330-6
- Evans, M.A., Smart, N., Dube, K.N., Bollini, S., Clark, J.E., Evans, H.G., Taams, L.S., Richardson, R., Levesque, M., Martin, P., Mills, K., Riegler, J., Price, A.N., Lythgoe, M.F., and Riley, P.R. (2013) Thymosin beta4-sulfoxide attenuates inflammatory cell infiltration and promotes cardiac wound healing. Nature communications. 4:2081
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