Gene

dock7

ID

ZDB-GENE-050302-15

Name

dedicator of cytokinesis 7

Symbol

dock7 Nomenclature History

Previous Names

fb93h07
im:7145816
im:7157388
wu:fb93h07

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in axonogenesis and regulation of Rho protein signal transduction. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be located in membrane. Is expressed in central nervous system; optic vesicle; and retina. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 23. Orthologous to human DOCK7 (dedicator of cytokinesis 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7157388 (1 image)
IMAGE:7157391 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dock7 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 23	Alliance	Developmental and epileptic encephalopathy 23	615859

Associated With dock7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR021816	Dedicator of cytokinesis C/D, N-terminal
Domain	IPR027007	C2 DOCK-type domain
Domain	IPR027357	DOCKER domain
Domain	IPR037808	Dedicator of cytokinesis C, C2 domain
Domain	IPR046769	DOCKER, Lobe A
Domain	IPR046770	DOCKER, Lobe B
Domain	IPR046773	DOCKER, Lobe C
Family	IPR026791	Dedicator of cytokinesis
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR043161	Dedicator of cytokinesis, C-terminal, lobe A
Homologous_superfamily	IPR043162	Dedicator of cytokinesis, C-terminal, lobe C

Domain Details Per Protein

Protein	Length	C2 DOCK-type domain	C2 domain superfamily	Dedicator of cytokinesis	Dedicator of cytokinesis C, C2 domain	Dedicator of cytokinesis C/D, N-terminal	Dedicator of cytokinesis, C-terminal, lobe A	Dedicator of cytokinesis, C-terminal, lobe C	DOCKER domain	DOCKER, Lobe A	DOCKER, Lobe B	DOCKER, Lobe C
UniProtKB:A0A8M9QB50 InterPro	2083
UniProtKB:A0A8M9QG48 InterPro	2142
UniProtKB:A0A8M9Q6Y2 InterPro	2136
UniProtKB:A0A8M9Q0M5 InterPro	2137
UniProtKB:A0A8M9QB41 InterPro	2133
UniProtKB:A0A8M1RR02 InterPro	2096
UniProtKB:A0A8M9PMX0 InterPro	2138
UniProtKB:A0A8M9Q6X7 InterPro	2144
UniProtKB:A0A8M2BD96 InterPro	2094
UniProtKB:A0A8M9Q6Y7 InterPro	2113
UniProtKB:A0A8M9Q6Z5 InterPro	2066
UniProtKB:A0A8M9QG66 InterPro	2064
UniProtKB:A0A8M9QG61 InterPro	2102
UniProtKB:A0A8M9PMX5 InterPro	2131
UniProtKB:A0A8M9QB36 InterPro	2140
UniProtKB:A0A8M2BD70 InterPro	2125
UniProtKB:A0A8M9QG53 InterPro	2135
UniProtKB:F1Q8Z1 InterPro	2129
UniProtKB:A0A8M9Q0P3 InterPro	1522
UniProtKB:A0A8M9PMZ3 InterPro	2079
UniProtKB:A0A8M2BD62 InterPro	2127

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dock7-201 (1) Ensembl	Ensembl	6,938 nt	Select Tool ZFIN BLAST
mRNA	dock7-202 (1) Ensembl	Ensembl	1,225 nt	Select Tool ZFIN BLAST
mRNA	dock7-205 (1) Ensembl	Ensembl	2,811 nt	Select Tool ZFIN BLAST
mRNA	dock7-206 (1) Ensembl	Ensembl	1,814 nt	Select Tool ZFIN BLAST
mRNA	dock7-207 (1) Ensembl	Ensembl	1,941 nt	Select Tool ZFIN BLAST
mRNA	dock7-208 (1) Ensembl	Ensembl	1,410 nt	Select Tool ZFIN BLAST
ncRNA	dock7-002 (1) Ensembl	Ensembl	929 nt	Select Tool ZFIN BLAST
ncRNA	dock7-004 (1) Ensembl	Ensembl	518 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations