Gene
cltcb
- ID
- ZDB-GENE-050227-12
- Name
- clathrin, heavy chain b (Hc)
- Symbol
- cltcb Nomenclature History
- Previous Names
-
- fd07f11
- im:7145213
- wu:fd07f11
- zgc:113234
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have clathrin light chain binding activity. Predicted to be involved in clathrin coat assembly; mitotic cell cycle; and receptor-mediated endocytosis. Predicted to localize to clathrin complex; clathrin-coated endocytic vesicle; and spindle. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 56. Orthologous to human CLTC (clathrin heavy chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7145213 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 56 | Alliance | Intellectual developmental disorder, autosomal dominant 56 | 617854 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR015348 | Clathrin, heavy chain, linker, core motif |
| Family | IPR016341 | Clathrin, heavy chain |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR016025 | Clathrin heavy chain, N-terminal |
| Repeat | IPR000547 | Clathrin, heavy chain/VPS, 7-fold repeat |
| Repeat | IPR022365 | Clathrin, heavy chain, propeller repeat |
Domain Details Per Protein
| Protein | Length | Armadillo-type fold | Clathrin, heavy chain | Clathrin, heavy chain, linker, core motif | Clathrin heavy chain, N-terminal | Clathrin, heavy chain, propeller repeat | Clathrin, heavy chain/VPS, 7-fold repeat | Tetratricopeptide-like helical domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E9QBV1
|
1677 | |||||||
|
UniProtKB:A0A8M2B3R2
|
1684 | |||||||
|
UniProtKB:A0A8M2B4A2
|
1678 | |||||||
|
UniProtKB:A0A8M2B3J4
|
1685 |
Interactions and Pathways
No data available
Plasmids
No data available