Gene
pdgfba
- ID
- ZDB-GENE-050208-525
- Name
- platelet-derived growth factor beta polypeptide a
- Symbol
- pdgfba Nomenclature History
- Previous Names
-
- pdgfb
- sb:eu1033
- si:ch211-79m20.1
- si:dkey-261d11.1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have platelet-derived growth factor receptor binding activity. Involved in angiogenesis; regulation of DNA replication; and tissue regeneration. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Is expressed in cardiovascular system; diencephalon; floor plate; head; and liver. Orthologous to human PDGFB (platelet derived growth factor subunit B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1033 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ando et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| basal ganglia calcification | Alliance | Basal ganglia calcification, idiopathic, 5 | 615483 |
| Meningioma, SIS-related | 607174 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cystine-knot cytokine | PDGF/VEGF domain | Platelet-derived growth factor, conserved site |
|---|---|---|---|---|
|
UniProtKB:A0A8M9Q3E7
|
463 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pdgfba-201
(1)
|
Ensembl | 1,736 nt | ||
| mRNA |
pdgfba-202
(1)
|
Ensembl | 1,195 nt | ||
| mRNA |
pdgfba-203
(1)
|
Ensembl | 2,516 nt |
Interactions and Pathways
No data available
Plasmids
No data available