Gene

pdgfba

ID

ZDB-GENE-050208-525

Name

platelet-derived growth factor beta polypeptide a

Symbol

pdgfba Nomenclature History

Previous Names

pdgfb
sb:eu1033
si:ch211-79m20.1
si:dkey-261d11.1

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have platelet-derived growth factor receptor binding activity. Involved in angiogenesis; regulation of DNA replication; and tissue regeneration. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in basal ganglia calcification; clear cell renal cell carcinoma; connective tissue cancer (multiple); familial meningioma; and prostatic hypertrophy. Is expressed in cardiovascular system; diencephalon; floor plate; head; and liver. Orthologous to human PDGFB (platelet derived growth factor subunit B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

19 figures from 13 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu1033 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Ando et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pdgfba Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
basal ganglia calcification	Alliance	Basal ganglia calcification, idiopathic, 5	615483
dermatofibrosarcoma protuberans	Alliance	Dermatofibrosarcoma protuberans	607907
		Meningioma, SIS-related	607174

Associated With pdgfba Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023581	Platelet-derived growth factor, conserved site
Domain	IPR000072	PDGF/VEGF domain
Homologous_superfamily	IPR029034	Cystine-knot cytokine

Domain Details Per Protein

Protein	Length	Cystine-knot cytokine	PDGF/VEGF domain	Platelet-derived growth factor, conserved site
UniProtKB:A0A8M9Q3E7 InterPro	463

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pdgfba-201 (1) Ensembl	Ensembl	1,736 nt	Select Tool ZFIN BLAST
mRNA	pdgfba-202 (1) Ensembl	Ensembl	1,195 nt	Select Tool
mRNA	pdgfba-203 (1) Ensembl	Ensembl	2,516 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations