Gene

pxk

ID

ZDB-GENE-050208-393

Name

PX domain containing serine/threonine kinase

Symbol

pxk Nomenclature History

Previous Names

sb:eu550
si:dkeyp-87e7.1

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including early endosome to late endosome transport; lysosomal transport; and negative regulation of ATP-dependent activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in early endosome and late endosome. Predicted to be extrinsic component of endosome membrane. Orthologous to human PXK (PX domain containing serine/threonine kinase like).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2005

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu550 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pxk Human Ortholog

No data available

Associated With pxk Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000719	Protein kinase domain
Domain	IPR001683	Phox homology
Domain	IPR003124	WH2 domain
Domain	IPR037903	MONaKA, PX domain
Family	IPR051837	Sorting Nexin/PX Domain-Containing Protein Kinase-Like
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036871	PX domain superfamily

Domain Details Per Protein

Protein	Length	MONaKA, PX domain	Phox homology	Protein kinase domain	Protein kinase-like domain superfamily	PX domain superfamily	Sorting Nexin/PX Domain-Containing Protein Kinase-Like	WH2 domain
UniProtKB:A0A8M9P497 InterPro	572
UniProtKB:A0A8M2BLB9 InterPro	516
UniProtKB:Q1LVS2 InterPro	575
UniProtKB:A0A8M2BL91 InterPro	574
UniProtKB:A0A8M3AMV8 InterPro	515