Gene

gtpbp2b

ID

ZDB-GENE-050208-373

Name

GTP binding protein 2b

Symbol

gtpbp2b Nomenclature History

Previous Names

gtpbp2
si:ch211-151i8.2 (1)
si:dkeyp-34c12.3

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Orthologous to human GTPBP2 (GTP binding protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7149726 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa44989	Allele with one point mutation	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With gtpbp2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Jaberi-Elahi syndrome	617988

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Associated With gtpbp2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000795	Translational (tr)-type GTP-binding domain
Domain	IPR004161	Translation elongation factor EFTu-like, domain 2
Domain	IPR035531	GTP binding protein 1-like, GTP-binding domain
Family	IPR050055	Elongation factor Tu GTPase
Homologous_superfamily	IPR009000	Translation protein, beta-barrel domain superfamily

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Domain Details Per Protein

Protein	Length	Elongation factor Tu GTPase	GTP binding protein 1-like, GTP-binding domain	P-loop containing nucleoside triphosphate hydrolase	Translational (tr)-type GTP-binding domain	Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal	Translation elongation factor EFTu-like, domain 2	Translation protein, beta-barrel domain superfamily
UniProtKB:A0A8M1PAI6 InterPro	605

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 22

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	gtpbp2b-201 (1) Ensembl	Ensembl		1,904 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEYP-34C12	BX321898	ZFIN Curated Data
Encodes	EST	IMAGE:7149726	CK686942	Thisse et al., 2004

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001351674 (1)	5637 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX321898 (1)	195042 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A8M1PAI6 (1)	605 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	GTPBP2	6	Ensembl:ENSG00000172432 Gene:54676 OMIM:607434 HGNC:4670	Amino acid sequence comparison (2) Phylogenetic tree (1)
Mouse	Gtpbp2	17	Ensembl:ENSMUSG00000023952 MGI:1860138 Gene:56055	Phylogenetic tree (1) Amino acid sequence comparison (1)

Citations

Include unpublished citations

Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41

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