cnnm2a

ID

ZDB-GENE-050208-36

Name

cyclin and CBS domain divalent metal cation transport mediator 2a

Symbol

cnnm2a Nomenclature History

Previous Names

im:7136247
si:ch211-67n3.4

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable magnesium ion transmembrane transporter activity. Acts upstream of or within brain development and magnesium ion homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; digestive system; midbrain hindbrain boundary neural keel; pleuroperitoneal region; and scale. Used to study schizophrenia. Human ortholog(s) of this gene implicated in renal hypomagnesemia 6. Orthologous to human CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7136247 (2 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 12 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cnnm2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
renal hypomagnesemia 6	Alliance	Hypomagnesemia 6, renal	613882
		Hypomagnesemia, seizures, and impaired intellectual development 1	616418

Associated With cnnm2a Via Experimental Models

Human Disease	Fish	Conditions	Citations
schizophrenia	cnnm2a^a357/a357	standard conditions	Thyme et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000644	CBS domain
Domain	IPR002550	CNNM, transmembrane domain
Domain	IPR044751	Ion transporter-like, CBS domain
Family	IPR045095	Ancient conserved domain protein family
Homologous_superfamily	IPR046342	CBS domain superfamily