Gene
alx4b
- ID
- ZDB-GENE-050208-140
- Name
- ALX homeobox 4b
- Symbol
- alx4b Nomenclature History
- Previous Names
-
- im:7142878
- si:ch73-220n21.1
- zgc:162606 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Predicted to be involved in multicellular organism development and regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in craniosynostosis and parietal foramina. Is expressed in several structures, including brain; eye; optic vesicle; pharyngeal arch; and swim bladder bud. Orthologous to human ALX4 (ALX homeobox 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7142878 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| frontonasal dysplasia 2 | Alliance | Frontonasal dysplasia 2 | 613451 |
| parietal foramina | Alliance | Parietal foramina 2 | 609597 |
| {Craniosynostosis 5, susceptibility to} | 615529 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003654 | OAR domain |
Domain Details Per Protein
| Protein | Length | OAR domain |
|---|---|---|
|
UniProtKB:A0A2R8RTN2
|
259 |
Interactions and Pathways
No data available
Plasmids
No data available