Gene
mecom
- ID
- ZDB-GENE-050208-123
- Name
- MDS1 and EVI1 complex locus
- Symbol
- mecom Nomenclature History
- Previous Names
-
- evi1
- im:7140716
- prdm3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have metal ion binding activity and nucleic acid binding activity. Involved in several processes, including embryonic cranial skeleton morphogenesis; endothelial to hematopoietic transition; and pronephric nephron development. Human ortholog(s) of this gene implicated in myeloid neoplasm. Is expressed in several structures, including brain; dorsal aorta; head; mesoderm; and pronephros. Orthologous to human MECOM (MDS1 and EVI1 complex locus).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Radioulnar synostosis with amegakaryocytic thrombocytopenia 2 | 616738 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | SET domain | SET domain superfamily | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M6YSJ7
|
1257 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available