Gene
ncstn
- ID
- ZDB-GENE-050131-1
- Name
- nicastrin
- Symbol
- ncstn Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to be involved in protein processing. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; hidradenitis suppurativa; and schizophrenia. Is expressed in several structures, including caudal fin; central nervous system; gill; heart; and otic vesicle. Orthologous to human NCSTN (nicastrin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Lim et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hidradenitis suppurativa | Alliance | Acne inversa, familial, 1 | 142690 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| vitiligo | ncstnhi1384Tg/hi1384Tg | standard conditions | Hsu et al., 2019 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Nicastrin | Nicastrin, small lobe |
|---|---|---|---|
|
UniProtKB:Q5XLR3
|
707 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available