Gene
prkacaa
- ID
- ZDB-GENE-050114-6
- Name
- protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
- Symbol
- prkacaa Nomenclature History
- Previous Names
-
- prkaca
- zgc:158799
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have protein kinase A regulatory subunit binding activity. Predicted to be involved in protein kinase A signaling. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; hypertrophic cardiomyopathy; and primary pigmented nodular adrenocortical disease. Orthologous to human PRKACA (protein kinase cAMP-activated catalytic subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Emerson et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
primary pigmented nodular adrenocortical disease 4 | Alliance | Cushing syndrome, ACTH-independent adrenal, somatic | 615830 |
Cardioacrofacial dysplasia 1 | 619142 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR000961 | AGC-kinase, C-terminal |
Family | IPR044109 | cAMP-dependent protein kinase catalytic subunit |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
Protein | Length | AGC-kinase, C-terminal | cAMP-dependent protein kinase catalytic subunit | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
---|---|---|---|---|---|---|---|
UniProtKB:A3KMS9
|
352 | ||||||
UniProtKB:A0A8M9PZU3
|
389 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
prkacaa-201
(1)
|
Havana | 6062 nt |
Interactions and Pathways
No data available
Plasmids
No data available