Gene

dclre1c

ID

ZDB-GENE-041210-72

Name

DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)

Symbol

dclre1c Nomenclature History

Previous Names

im:7141637
si:dkey-153k10.3
zgc:136877

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have 5'-3' exodeoxyribonuclease activity and damaged DNA binding activity. Predicted to be involved in double-strand break repair via nonhomologous end joining; interstrand cross-link repair; and protection from non-homologous end joining at telomere. Predicted to localize to nonhomologous end joining complex and nuclear chromosome, telomeric region. Human ortholog(s) of this gene implicated in Omenn syndrome; common variable immunodeficiency; severe combined immunodeficiency; and severe combined immunodeficiency with sensitivity to ionizing radiation. Orthologous to human DCLRE1C (DNA cross-link repair 1C).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7141637 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dclre1c Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Omenn syndrome	Alliance	Omenn syndrome	603554
severe combined immunodeficiency with sensitivity to ionizing radiation	Alliance	Severe combined immunodeficiency, Athabascan type	602450

Associated With dclre1c Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001279	Metallo-beta-lactamase
Domain	IPR011084	DNA repair metallo-beta-lactamase
Homologous_superfamily	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

Domain Details Per Protein

Protein	Length	DNA repair metallo-beta-lactamase	Metallo-beta-lactamase	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
UniProtKB:A0A8M9Q5Y8 InterPro	639
UniProtKB:Q5RGE5 InterPro	639
UniProtKB:A0A8M9Q5Y6 InterPro	680
UniProtKB:A0A8M9PHC7 InterPro	379
UniProtKB:A0A8M6YZK4 InterPro	663

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dclre1c-201 (1) Ensembl	Ensembl	2,400 nt	Select Tool
mRNA	dclre1c-203 (1) Ensembl	Ensembl	689 nt	Select Tool
ncRNA	dclre1c-002 (1) Ensembl	Ensembl	880 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations