Gene
crtc1b
- ID
- ZDB-GENE-041210-266
- Name
- CREB regulated transcription coactivator 1b
- Symbol
- crtc1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have cAMP response element binding protein binding activity. Predicted to be involved in positive regulation of CREB transcription factor activity and positive regulation of transcription by RNA polymerase II. Predicted to localize to cytoplasm and nucleus. Orthologous to human CRTC1 (CREB regulated transcription coactivator 1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 1 figure from Pei et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Mucoepidermoid salivary gland carcinoma |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | CREB-regulated transcription coactivator | Transducer of regulated CREB activity, C-terminal | Transducer of regulated CREB activity, middle domain | Transducer of regulated CREB activity, N-terminal |
---|---|---|---|---|---|
UniProtKB:F1QYY6
|
583 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
crtc1b-201
(1)
|
Ensembl | 2,449 nt | ||
mRNA |
crtc1b-202
(1)
|
Ensembl | 1,693 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-255D18 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001365302 (1) | |||
Genomic | GenBank:BX936438 | 188269 nt | ||
Polypeptide | UniProtKB:F1QYY6 (1) | 583 aa |
- Tonelli, F., Leoni, L., Daponte, V., Gioia, R., Cotti, S., Fiedler, I.A.K., Larianova, D., Willaert, A., Coucke, P.J., Villani, S., Busse, B., Besio, R., Rossi, A., Witten, P.E., Forlino, A. (2023) Zebrafish Tric-b is required for skeletal development and bone cells differentiation. Frontiers in endocrinology. 14:10029141002914
- Forte-Gomez, H.F., Gioia, R., Tonelli, F., Kobbe, B., Koch, P., Bloch, W., Paulsson, M., Zaucke, F., Forlino, A., Wagener, R. (2022) Structure, evolution and expression of zebrafish cartilage oligomeric matrix protein (COMP, TSP5). CRISPR-Cas mutants show a dominant phenotype in myosepta. Frontiers in endocrinology. 13:10006621000662
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Pei, D.S., Yang, X.J., Liu, W., Guikema, J.E., Schrader, C.E., and Strauss, P.R. (2011) A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta. Nucleic acids research. 39(8):3156-3165
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