Gene
grip1
- ID
- ZDB-GENE-041210-125
- Name
- glutamate receptor interacting protein 1
- Symbol
- grip1 Nomenclature History
- Previous Names
-
- si:dkey-244b23.1
- si:dkey-6a5.1
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to be involved in neurotransmitter receptor transport, endosome to postsynaptic membrane. Predicted to be located in cytoplasm. Is expressed in brain; eye; median fin fold; and somite. Human ortholog(s) of this gene implicated in Fraser syndrome 3. Orthologous to human GRIP1 (glutamate receptor interacting protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Clark et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024414Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024415Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mn0078Gt | Transgenic insertion | Unknown | Unknown | DNA | |
| sa17341 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33422 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa40251 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-grip1 | N/A | Carney et al., 2010 |
| MO2-grip1 | N/A | Carney et al., 2010 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fraser syndrome 3 | Alliance | Fraser syndrome 3 | 617667 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Glutamate receptor-interacting protein 1/2 | PDZ domain | PDZ domain 6 | PDZ superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M3ARB1
|
1095 | ||||
|
UniProtKB:A0A8M3ARA1
|
1171 | ||||
|
UniProtKB:A0A8M3ARI0
|
1191 | ||||
|
UniProtKB:Q5TZH0
|
1143 | ||||
|
UniProtKB:A0A8M3AYN5
|
1110 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-6A5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-147I20 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-244B23 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198319 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198321 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044851 (1) | 3432 nt | ||
| Genomic | GenBank:BX119963 (1) | 229125 nt | ||
| Polypeptide | UniProtKB:A0A8M3ARI0 (1) | 1191 aa |
- Falisse, E., Ducos, B., Stockwell, P.A., Morison, I.M., Chatterjee, A., Silvestre, F. (2018) DNA methylation and gene expression alterations in zebrafish early-life stages exposed to the antibacterial agent triclosan. Environmental pollution (Barking, Essex : 1987). 243:1867-1877
- Tian, J., Shao, J., Liu, C., Hou, H.Y., Chou, C.W., Shboul, M., Li, G.Q., El-Khateeb, M., Samarah, O.Q., Kou, Y., Chen, Y.H., Chen, M.J., Lyu, Z., Chen, W.L., Chen, Y.F., Sun, Y.H., Liu, Y.W. (2018) Deficiency of lrp4 in zebrafish and human LRP4 mutation induce aberrant activation of Jagged-Notch signaling in fin and limb development. Cellular and molecular life sciences : CMLS. 76(1):163-178
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Hensley, M.R., Chua, R.F., Leung, Y.F., Yang, J.Y., Zhang, G. (2016) Molecular Evolution of MDM1, a "Duplication-Resistant" Gene in Vertebrates. PLoS One. 11:e0163229
- Talbot, J.C., Nichols, J.T., Yan, Y.L., Leonard, I.F., BreMiller, R.A., Amacher, S.L., Postlethwait, J.H., Kimmel, C.B. (2016) Pharyngeal morphogenesis requires fras1-itga8- dependent epithelial-mesenchymal interaction. Developmental Biology. 416(1):136-48
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Westcot, S.E., Hatzold, J., Urban, M.D., Richetti, S.K., Skuster, K.J., Harm, R.M., Lopez Cervera, R., Umemoto, N., McNulty, M.S., Clark, K.J., Hammerschmidt, M., Ekker, S.C. (2015) Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis. PLoS One. 10:e0130688
- Ge, X., Grotjahn, D., Welch, E., Lyman-Gingerich, J., Holguin, C., Dimitrova, E., Abrams, E.W., Gupta, T., Marlow, F.L., Yabe, T., Adler, A., Mullins, M.C., Pelegri, F. (2014) Hecate/Grip2a acts to reorganize the cytoskeleton in the symmetry-breaking event of embryonic axis induction. PLoS Genetics. 10(6):e1004422
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Moore, F.E., Reyon, D., Sander, J.D., Martinez, S.A., Blackburn, J.S., Khayter, C., Ramirez, C.L., Joung, J.K., and Langenau, D.M. (2012) Improved Somatic Mutagenesis in Zebrafish Using Transcription Activator-Like Effector Nucleases (TALENs). PLoS One. 7(5):e37877
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