Gene
pcdh2ab1
- ID
- ZDB-GENE-041118-1
- Name
- protocadherin 2 alpha b 1
- Symbol
- pcdh2ab1 Nomenclature History
- Previous Names
-
- DrPcdh2a26 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including PCDHA1 (protocadherin alpha 1); PCDHA10 (protocadherin alpha 10); and PCDHA12 (protocadherin alpha 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Tada et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-pcdh2a | N/A | Emond et al., 2008 |
| MO2-pcdh2a | N/A | Emond et al., 2008 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cadherin conserved site | Cadherin, C-terminal catenin-binding domain | Cadherin, cytoplasmic C-terminal domain | Cadherin-like | Cadherin-like superfamily | Cadherin, N-terminal | Protocadherin/Cadherin-related Cell Adhesion |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q60I76
|
941 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pcdh2ab1-201
(1)
|
Ensembl | 3,317 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-262J3 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-115D7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195069 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195094 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001009588 (1) | 3443 nt | ||
| Genomic | GenBank:AL929558 (1) | 170597 nt | ||
| Polypeptide | UniProtKB:Q60I76 (1) | 941 aa |
No data available
- Emond, M.R., and Jontes, J.D. (2008) Inhibition of protocadherin-alpha function results in neuronal death in the developing zebrafish. Developmental Biology. 321(1):175-187
- Noonan, J.P., Grimwood, J., Schmutz, J., Dickson, M., and Myers, R.M. (2004) Gene conversion and the evolution of protocadherin gene cluster diversity. Genome research. 14(3):354-366
- Tada, M.N., Senzaki, K., Tai, Y., Morishita, H., Tanaka, Y.Z., Murata, Y., Ishii, Y., Asakawa, S., Shimizu, N., Sugino, H., and Yagi, T. (2004) Genomic organization and transcripts of the zebrafish Protocadherin genes. Gene. 340(2):197-211
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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